SV2B is essential for the integrity of the glomerular filtration barrier

Laboratory Investigation; a Journal of Technical Methods and Pathology
Yoshiyasu FukusumiHiroshi Kawachi

Abstract

The glomerular visceral epithelial cell (podocyte) is characterized as a specialized structure of the interdigitating foot processes, covering the outer side of the glomerular basement membrane (GBM). The neighboring foot processes are connected by a slit diaphragm, which is a key structure regulating the barrier function of the glomerular capillary wall to prevent proteinuria. We have previously reported that synaptic vesicle protein 2 B (SV2B) is expressed in the podocyte and that the expression is clearly decreased in nephrotic models. However, the precise function of SV2B in the podocyte is unclear. To investigate the role of SV2B in maintaining the podocyte function and to better understand the function of the neuron-like vesicle expressing SV2B in the podocyte, we analyzed them with SV2B knockout (KO) mice. An increase in the amount of proteinuria, effacement of the foot process of the podocyte, and alterations of the GBM were detected in SV2B KO mice. It was also found that the expression of CD2AP, nephrin, and NEPH1, the functional molecules of the slit diaphragm, and laminin, a critical component of the GBM, is clearly altered in SV2B KO mice. Synaptotagmin and neurexin, which have a role in the synaptic vesicle dockin...Continue Reading

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Citations

Apr 1, 2018·Journal of the American Society of Nephrology : JASN·Yoshiyasu FukusumiHiroshi Kawachi
Feb 6, 2020·Clinical and Experimental Nephrology·Hiroshi Kawachi, Yoshiyasu Fukusumi
Mar 22, 2020·European Journal of Pediatrics·Trine KorsgaardSøren Rittig
Jul 16, 2020·Bioscience Reports·Yu ZhangHu-Bin Duan
Apr 23, 2021·The American Journal of Pathology·Yoshiyasu FukusumiHiroshi Kawachi
Oct 17, 2021·Scientific Reports·Akiko TanoueKaoru Dohi

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