PMID: 6159551Nov 13, 1980Paper

SV40 large T shares an antigenic determinant with a cellular protein of molecular weight 68,000

Nature
D Lane, W K Hoeffler

Abstract

The large T protein coded by the early region of simian virus 40 (SV40) is involved in the induction and maintenance of cell transformation. It is not clear which properties of T are important in causing the transformation, since the protein is multifunctional. To clarify the action of T proteins in transformation, we have prepared several monoclonal antibodies directed against different regions of the T molecule. One of these antibodies, DL 3C4, recognizes an antigenic determinant on T that is also present on a host cell protein of molecular weight 68,000. This cross-reactive 68K protein is located within the nucleus of all mammalian cell types examined and has a characteristic granular distribution as shown by immunofluorescence. The antigenic determinant recognized by DL 3C4 is resistant to denaturation. Studies on Adeno-SV40 hybrid viruses show that the antigenic site on T is coded for by sequences located between 0.44 and 0.29 on the SV40 map.

References

Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J RenartG R Stark
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R TjianA Graessmann
Mar 15, 1979·Nature·D P Lane, L V Crawford
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R Tjian, A Robbins
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J D GriffinD M Livingston
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M S CollettR L Erikson
Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·K Burridge
Oct 1, 1972·Journal of Virology·P Tegtmeyer
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R B CarrollR Dulbecco

❮ Previous
Next ❯

Citations

Dec 22, 1999·Cell Biology International·S ChandrasekharA I Daud
Jan 1, 1984·Journal of Cancer Research and Clinical Oncology·H Busch
Jan 1, 1982·Medical Microbiology and Immunology·H Koprowski
Jan 1, 1989·Immunologic Research·R S Fujinami, M B Oldstone
Jan 1, 1981·Journal of Immunological Methods·D P Lane, E B Lane
Jan 22, 2004·Biochemical and Biophysical Research Communications·Liuqing YangZhi Ren Liu
May 12, 2005·Clinical Biochemistry·Mohamed Abdelhaleem
Sep 30, 2009·Cell Research·Haizhen WangZhi-Ren Liu
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E A NiggS J Singer
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S M Dilworth, B E Griffin
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S S Katiyar, J W Porter
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R IggoN K Spurr
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W D HamiltonR Tanese
May 1, 1984·The Journal of Experimental Medicine·R L RubinA N Theofilopoulos
May 25, 1990·Nucleic Acids Research·P HlochH Stahl
Sep 25, 1990·Nucleic Acids Research·R IggoD P Lane
Apr 11, 1992·Nucleic Acids Research·E Schärer, R Iggo
Jan 29, 2000·Nucleic Acids Research·O G RösslerH Stahl
Jul 24, 2002·Nucleic Acids Research·Heike Uhlmann-SchifflerHans Stahl
Feb 22, 2003·Nucleic Acids Research·V C OgilvieF V Fuller-Pace
Jun 22, 2013·Nucleic Acids Research·Verena GeißlerHans Stahl
Oct 9, 2002·Genes & Development·Akira IshizukaHaruhiko Siomi
Feb 4, 2010·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Yook Wah ChoiYee Joo Tan
Feb 1, 1992·Molecular Microbiology·S R Schmid, P Linder
Apr 4, 2014·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Michael B A Oldstone
Jan 1, 1991·International Reviews of Immunology·C NickersonC David
Jan 1, 1982·CRC Critical Reviews in Biochemistry·B Schaffhausen
Sep 25, 1998·Critical Reviews in Biochemistry and Molecular Biology·A LükingU Schmidt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.