PMID: 22587788May 17, 2012Paper

SVM prediction of ligand-binding sites in bacterial lipoproteins employing shape and physio-chemical descriptors

Protein and Peptide Letters
Kiran KadamV K Jayaraman

Abstract

Bacterial lipoproteins play critical roles in various physiological processes including the maintenance of pathogenicity and numbers of them are being considered as potential candidates for generating novel vaccines. In this work, we put forth an algorithm to identify and predict ligand-binding sites in bacterial lipoproteins. The method uses three types of pocket descriptors, namely fpocket descriptors, 3D Zernike descriptors and shell descriptors, and combines them with Support Vector Machine (SVM) method for the classification. The three types of descriptors represent shape-based properties of the pocket as well as its local physio-chemical features. All three types of descriptors, along with their hybrid combinations are evaluated with SVM and to improve classification performance, WEKA-InfoGain feature selection is applied. Results obtained in the study show that the classifier successfully differentiates between ligand-binding and non-binding pockets. For the combination of three types of descriptors, 10 fold cross-validation accuracy of 86.83% is obtained for training while the selected model achieved test Matthews Correlation Coefficient (MCC) of 0.534. Individually or in combination with new and existing methods, our m...Continue Reading

Citations

Feb 18, 2016·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Preethi RanganarayananVigneshwar Ramakrishnan

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