Swainsonine, a potent mannosidase inhibitor, elevates rat liver and brain lysosomal alpha-D-mannosidase, decreases Golgi alpha-D-mannosidase II, and increases the plasma levels of several acid hydrolases

Archives of Biochemistry and Biophysics
D R Tulsiani, O Touster

Abstract

Swainsonine, a toxic plant alkaloid reported to be the agent that induces in animals a neurological condition very similar to the hereditary lysosomal storage disease mannosidosis, and to inhibit the formation of complex glycoproteins of the asparagine-linked class, was recently shown [D.R.P. Tulsiani, T.M. Harris, and O. Touster, (1982) J. Biol. Chem. 257, 7936-7939] to be a highly potent and specific inhibitor of Golgi mannosidase II in addition to being a strong inhibitor of lysosomal mannosidase. In the present study the effect of administered swainsonine on tissue enzyme levels was investigated. The activity of Golgi mannosidase II was markedly decreased (22% of control) without changes occurring in the activities of several other Golgi enzymes. However, the effects of swainsonine on lysosomal enzymes was unexpected. In liver, acid mannosidase increased markedly, instead of decreasing as would be expected from a compound reported to induce a mannosidosis-like condition. Similarly, the principal change in brain was a substantial increase in lysosomal mannosidase levels. In plasma, most lysosomal enzymes increased. These results indicate that the pathological effects of swainsonine are not solely attributable to its being an...Continue Reading

References

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Citations

Jan 1, 1987·The International Journal of Biochemistry·A Jauhiainen, T Vanha-Perttula
Jan 1, 1987·Pharmacology & Therapeutics·R DatemaP A Romero
Jun 24, 1985·Biochimica Et Biophysica Acta·U FuhrmannH Ploegh
Aug 1, 1985·The Journal of Cell Biology·P M NovikoffD P Tulsiani
Sep 2, 2009·Protein Science : a Publication of the Protein Society·Meenakshi VenkatesanDavid R Rose
Nov 24, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M A Kukuruzinska, K Lennon
Jan 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wenyue WangZhicheng Xiao
Jun 15, 2018·PloS One·M Kristen HallRuth A Schwalbe
Oct 31, 1983·FEBS Letters·D J AbrahamA Dell
Apr 1, 1988·Archives of Biochemistry and Biophysics·Y NishimuraK Kato
Jan 1, 1989·Critical Reviews in Oncology/hematology·M M Mareel, M De Mets
Nov 15, 1983·Biochemical and Biophysical Research Communications·R G Arumugham, M L Tanzer
Nov 29, 2005·Science·Henri de la SalleGennaro De Libero

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