SWAP-70-deficient mast cells are impaired in development and IgE-mediated degranulation

European Journal of Immunology
Brigitte GrossRolf Jessberger

Abstract

Cross-linking of the high-affinity IgE receptor (FcepsilonRI) on mast cell activates signaling pathways that trigger degranulation and the release of multiple pro-inflammatory mediators. Mature,immature and precursor mast cells are degranulation competent. We show here that the signaling protein SWAP-70 has a function in mast cell biology. While not found in many cell types, we find that apart from B cells, mast cells also express SWAP-70. In activated B cells, SWAP-70 shuttles between cytoplasm and nucleus, but in mast cells it is confined to the cytoplasm. SWAP-70(ko/ko) (double knockout) mice have reduced numbers of mature mast cells, and these are degranulation competent. However, although immature mast cells from SWAP-70(ko/ko) mice respond normally to SCF and IL-3 and have functional granules, their FcepsilonRI-mediated degranulation is inhibited. Thus, in mast cells SWAP-70 plays a role both in establishing the initial competence to degranulate and to develop into mature mast cells.

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Citations

Sep 20, 2008·Blood·Carlos Ocana-MorgnerRolf Jessberger
Nov 16, 2004·Molecular and Cellular Biology·Raja Rajeswari Sivalenka, Rolf Jessberger
Sep 2, 2011·Haematologica·Tatsiana Ripich, Rolf Jessberger
Jun 1, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Annette I GarbeRolf Jessberger
Feb 1, 2008·European Journal of Immunology·Raja R SivalenkaRolf Jessberger
Jun 9, 2005·Blood·Elena VigoritoMartin Turner
Jan 15, 2020·Journal of Cell Science·Viktoria Betaneli, Rolf Jessberger
Jan 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nooshin S BahaieP Sriramarao
Mar 21, 2006·Microbiology and Immunology·Noriaki KimbaraNoriko Okada
Mar 21, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jing LiuYan-Ling Wang
Aug 19, 2009·European Journal of Immunology·Uwe SchmidtWilfried Ellmeier
May 28, 2004·Applied Immunohistochemistry & Molecular Morphology : AIMM·Amy E HeeremaBrian G Herndier
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu-Nee LeePeter Angel
May 5, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carlos Ocaña-MorgnerRolf Jessberger
May 20, 2017·International Journal of Inflammation·Marie HashimotoYoshihiko Tanaka
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Björn TextorBettina Hartenstein
Jan 19, 2006·Journal of Cell Science·Sayoko IharaYasuhisa Fukui
Oct 19, 2006·European Journal of Cell Biology·Pia OberbanscheidtMartin Bähler
Oct 5, 2021·European Journal of Immunology·Theres KlewerRolf Jessberger
Aug 31, 2011·Molecular and Cellular Neurosciences·Norio Takada, Bruce Appel

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