PMID: 25787994Mar 20, 2015Paper

Swapping of interaction partners with ATG5 for autophagosome maturation

BMB Reports
Jun Hoe Kim, Hyun Kyu Song

Abstract

Autophagy is a tightly regulated lysosome-mediated catabolic process in eukaryotes that maintains cellular homeostasis. A distinguishable feature of autophagy is the formation of double-membrane structures, autophagosome, which envelopes the intracellular cargoes and finally degrades them by fusion with lysosomes. So far, many structures of Atg proteins working on the autophagosome formation have been reported, however those involved in autophagosome maturation, a fusion with lysosome, are relatively unknown. One of the molecules in autophagosome maturation, TECPR1, has been identified and recently, structural studies on both ATG5-TECPR1 and ATG5-ATG16L1 complexes revealed that TECPR1 and ATG16L1 share the same binding site on ATG5. These results, in combination with supporting biochemical and cellular biological data, provide an insight into a model for swapping ATG5 partners for autophagosome maturation.

Citations

Mar 8, 2017·Scientific Reports·Byeong-Won KimHyun Kyu Song
Aug 2, 2017·Expert Opinion on Drug Discovery·Hui-Yun HwangHo Jeong Kwon
Nov 8, 2018·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Yongzhu LvJianjun Gao
Dec 25, 2015·BMB Reports·Byeong-Won KimHyun Kyu Song

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