Sweat testing for cystic fibrosis: A review of New Zealand laboratories

Journal of Paediatrics and Child Health
Richard MackayJ M Kirk

Abstract

Evolving diagnostic criteria for cystic fibrosis, broadening of the populations being tested and the need to interpret intermediate sweat test results have imposed a much greater need to standardize the collection and analysis of sweat. To identify variations in sweat testing in New Zealand laboratories and compare these with guidelines from the UK and the USA. All laboratories in New Zealand offering sweat testing were identified and data collected from these laboratories by structured questionnaire. There were no New Zealand laboratories that conformed to either set of guidelines. Inconsistencies were observed in minimum sweat quantities, the nature of the iontophoresis solution, the sweat electrolytes analysed, quoted reference ranges and recommendations made as a consequence of the result. Conformity to the guidelines would help to minimize variation in sweat testing in New Zealand. Performance of a sufficient number of tests to maintain expertise is critical, but geographical constraints make patient travel to distant centres difficult in a small, scattered population. A possible solution, where numbers permit, may be the collection of sweat locally, with referral to a major laboratory for analysis. This is only possible w...Continue Reading

References

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May 9, 2000·Archives of Disease in Childhood·J M Kirk
Oct 27, 2004·American Journal of Physical Anthropology·Sonya K Owers, Robert F Pastor
Jun 28, 2005·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Jonathan McCormickAnil Mehta
Feb 3, 2007·Annals of Clinical Biochemistry·Anne GreenUNKNOWN Guidelines Development Group

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Citations

Feb 7, 2016·Clinical Biochemistry·Marco SalvatoreDomenica Taruscio
Sep 10, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Anne Lindegaard Christiansen, Mads Nybo
Apr 25, 2006·Journal of Paediatrics and Child Health·John Massie
Nov 20, 2013·Pediatric Pulmonology·Jake T B CollieRonda F Greaves
Dec 17, 2014·BMC Pulmonary Medicine·Carla Cristina Souza GomezJose Dirceu Ribeiro
May 6, 2008·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Natalia CirilliUNKNOWN ICFS Sweat Test Working Group
Aug 30, 2008·The Korean journal of laboratory medicine·Sue Jung KimJeong-Ho Kim
Jun 3, 2009·Annals of Clinical Biochemistry·John CoakleyHeather Robins
Oct 11, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Ronda F GreavesUNKNOWN Australasian Association of Clinical Biochemists Sweat Test Working Party in association with the Royal Australasian College
Jun 11, 2019·The Annals of the American Academy of Political and Social Science·Timothy M Smeeding
May 26, 2017·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Maria Fátima ServidoniUNKNOWN Grupo Colaborativo de Estudos em Fibrose Cística
Sep 16, 2018·BMC Pulmonary Medicine·Carla Cristina Souza GomezFrancisco Ubaldo Vieira Junior
Apr 8, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Freerk PrenzelJulia Hentschel

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