PMID: 6404469Apr 30, 1983Paper

Sweat tests to diagnose cystic fibrosis in adults

British Medical Journal
M E HodsonJ C Batten

Abstract

Twenty five patients with cystic fibrosis and 25 controls were studied to define a sweat sodium concentration in adults that could be taken as diagnostic of cystic fibrosis. Some of the controls had a sweat sodium concentration of over 50 mmol(mEq)/l, and thus cystic fibrosis should be diagnosed in an adult only when two measurements of sweat sodium concentration are above 70 mmol/l. In cases in which the sweat sodium concentration was borderline a suppression test using fludrocortisone improved the accuracy of diagnosis; this test entails recording the lowest concentration reached after administration of the drug. A scatter diagram of the baseline sweat sodium concentrations plotted against the lowest concentration attained after suppression with fludrocortisone may aid the diagnosis further.

References

Jan 1, 1979·Clinical and Experimental Immunology·F CarswellM Silverman

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Citations

Jul 4, 1985·The New England Journal of Medicine·A E HardingD P Muller
Nov 1, 1986·Archives of Disease in Childhood·J M Littlewood
Feb 1, 1997·Archives of Disease in Childhood·C Wallis
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