Swedish children with hereditary angioedema report good overall health and quality of life despite symptoms

Acta Paediatrica
Anders NygrenCarl-Fredrik Wahlgren

Abstract

Few studies have been published on children with hereditary angioedema (HAE), an autosomal dominant disease caused by mutations on chromosome 11. This study explored various aspects of the disease in the Swedish paediatric population. A retrospective questionnaire was sent to all 36 Swedish children known to have HAE, and a physician carried out follow-up telephone interviews. Most of the questionnaires were completed by the parents of 31 (86%) children with HAE, with or without their input, at a median age of nine years (range 1-17), and the physician also interviewed 29. HAE symptoms were experienced by 23 children, including abdominal attacks (96%), skin swelling (78%) and swelling in the mouth and/or upper airways (52%). Psychological stress was the most common trigger for abdominal attacks and trauma and sports triggered skin swelling. The majority (n = 19) had access to complement-1 esterase inhibitor concentrate at home. Current health and quality of life were generally rated as good, independent of whether the child had experienced HAE symptoms or not. Most children with HAE had experienced abdominal attacks and skin swelling, but their overall health and quality of life were generally perceived to be good.

References

Jul 1, 1982·The American Journal of the Medical Sciences·M CicardiA Agostoni
Feb 1, 1994·Pediatric Research·E W NielsenT E Mollnes
Dec 12, 2000·The Journal of Allergy and Clinical Immunology·E PappalardoM Tosi
Jul 30, 2002·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Henriette FarkasBeáta Visy
Sep 10, 2004·The Journal of Allergy and Clinical Immunology·Angelo AgostoniLorenza Zingale
Feb 26, 2005·Clinical and Experimental Immunology·M M GompelsD Watters
May 7, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Olga RocheMargarita López-Trascasa
Jun 10, 2005·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Robert J BoyleMimi L K Tang
Jun 23, 2005·Human Mutation·Olga RocheMargarita López-Trascasa
Feb 9, 2006·The American Journal of Gastroenterology·Konrad BorkJochen Hardt
Feb 24, 2006·The American Journal of Medicine·Konrad BorkJochen Hardt
Aug 29, 2007·Pediatrics·Henriette FarkasTom Bowen
Jan 29, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Tom BowenZhi Yu Xiang
Aug 28, 2009·The British Journal of Dermatology·A Bygum
Jul 3, 2010·Paediatric Drugs·Didier G EboWim J Stevens
Jul 30, 2010·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Henriette Farkas
Jul 30, 2010·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Tom BowenZhi Yu Xiang
Feb 7, 2012·Lancet·Hilary Longhurst, Marco Cicardi
Apr 1, 2011·The World Allergy Organization Journal·Allen P Kaplan
Jan 4, 2013·The World Allergy Organization Journal·Timothy CraigMarcus Maurer
Jul 6, 2014·Orphanet Journal of Rare Diseases·Emel Aygören-PürsünTeresa Caballero
Aug 13, 2014·Clinical and Experimental Immunology·N ReadK J Fidler
Jan 7, 2015·Allergy and Asthma Proceedings·Gregory Bennett, Timothy Craig
Jan 23, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Maya K NandaAmal H Assa'ad

❮ Previous
Next ❯

Citations

Jul 12, 2017·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Aharon KesselBatya Engel-Yeger
Jan 29, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Maryam AyaziZahra Pourpak
Mar 5, 2017·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Batya Engel-YegerAharon Kessel
Jan 7, 2021·Allergy and Asthma Proceedings·Livia SavareseMaria Francesca Freda
Sep 9, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Paula J BusseBruce L Zuraw
Sep 11, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·M MaurerUNKNOWN IOS Study Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Related Papers

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
F GiardinoS Neri
Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Timothy J CraigAndrew J MacGinnitie
Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Renate KrügerVolker Wahn
© 2021 Meta ULC. All rights reserved