Sweet and bitter taste stimuli activate VTA projection neurons in the parabrachial nucleus

Brain Research
J D BoughterKenichi Tokita

Abstract

This study investigated neural projections from the parabrachial nucleus (PBN), a gustatory and visceral processing area in the brainstem, to the ventral tegmental area (VTA) in the midbrain. The VTA contains a large population of dopaminergic neurons that have been shown to play a role in reward processing. Anterograde neural tracing methods were first used to confirm that a robust projection from the caudal PBN terminates in the dorsal VTA; this projection was larger on the contralateral side. In the next experiment, we combined dual retrograde tracing from the VTA and the gustatory ventral posteromedial thalamus (VPMpc) with taste-evoked Fos protein expression, which labels activated neurons. Mice were stimulated through an intraoral cannula with sucrose, quinine, or water, and PBN sections were processed for immunofluorescent detection of Fos and retrograde tracers. The distribution of tracer-labeled PBN neurons demonstrated that the populations of cells projecting to the VTA or VPMpc are largely independent. Quantification of cells double labeled for Fos and either tracer demonstrated that sucrose and quinine were effective in activating both pathways. These results indicate that information about both appetitive and avers...Continue Reading

References

Dec 6, 1974·Brain Research·R Norgren
Jul 15, 1973·The Journal of Comparative Neurology·R Norgren, C M Leonard
Sep 22, 1980·Brain Research·C B Saper, A D Loewy
Mar 14, 1997·Science·W SchultzP R Montague
Dec 22, 1998·Brain Research. Brain Research Reviews·K C Berridge, T E Robinson
Apr 24, 1999·Trends in Neurosciences·P RedgraveK Gurney
Jul 23, 1999·Annals of the New York Academy of Sciences·M D CassellC Shi
Jun 6, 2000·Journal of Neuroscience Methods·T R Franklin, J P Druhan
Aug 23, 2001·Brain Research·A Hajnal, R Norgren
Aug 23, 2002·Behavioural Brain Research·Tsuyoshi ShimuraTakashi Yamamoto
Nov 26, 2002·Brain Research·Hamid KarimnamaziJoseph B Travers
Aug 23, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andras HajnalRalph Norgren
Nov 16, 2004·Trends in Neurosciences·Mark A Ungless
Mar 15, 2005·Physiology & Behavior·Andras Hajnal, Ralph Norgren
Aug 26, 2006·The European Journal of Neuroscience·José Martínez-HernándezFernando Martínez-García
Feb 9, 2007·Archives of Histology and Cytology·Takashi Yamamoto
Oct 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cedrick D Dotson, Alan C Spector
Mar 4, 2008·Psychopharmacology·Kent C Berridge, Morten L Kringelbach
Jul 8, 2008·Journal of Neuroendocrinology·K J Kovács
Jul 19, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Suriyaphun S MungarndeeRalph Norgren
Mar 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Frédéric BrischouxMark A Ungless
Mar 31, 2009·Neuroscience·K TokitaJ D Boughter
Aug 11, 2010·The Journal of Cell Biology·Nirupa Chaudhari, Stephen D Roper
Feb 11, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dianne P FiglewiczAryana Zavosh

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Citations

Aug 29, 2020·The Journal of Comparative Neurology·Anna I DuniganAaron G Roseberry
Jan 13, 2021·Nature Communications·Brooke C JarvieRichard D Palmiter
Apr 11, 2021·Physiology & Behavior·Elizabeth G Mietlicki-BaaseDerek Daniels

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