Sweet and CRISP(R)y parasite engineering.

The Journal of Biological Chemistry
Iain B H Wilson, Irma Schabussova

Abstract

Toxoplasma gondii is an intracellular parasite that is highly prevalent within human populations. Its genome encodes a range of enzymes involved in glycan biosynthesis and metabolism. A new study presents a library of CRISPR/Cas9-based glyco-relevant gene knockouts and their examination in glycomic and functional assays. This new resource can pave the way for a better understanding of the role of carbohydrates in infection and immunomodulation by this significant protozoan parasite.

References

Oct 22, 2008·International Journal for Parasitology·Angelika WagnerUrsula Wiedermann
Nov 23, 2018·The Journal of Biological Chemistry·Elisabet Gas-PascualChristopher M West

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Ribonucleases Deactivation

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.

CRISPR (general)

Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). CRISPR-Cas system enables the editing of genes to create or correct mutations. Discover the latest research on CRISPR here.

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
J S Remington, R Hackman
Infection and Immunity
K A Joiner, J F Dubremetz
Journal of the American Veterinary Medical Association
J P DubeyK Kiryu
© 2022 Meta ULC. All rights reserved