Sweet and sweetness-inducing activities of new triterpene glycosides, strogins

Chemical Senses
D SugitaY Kurihara

Abstract

In a previous study we isolated homologues of new oleanane-type triterpene glycosides from leaves of Staurogyne merguensis Kuntze and named them strogins. Strogins themselves have a sweet taste (sweet activity), which diminishes in a few minutes. Subsequent application of cold water to the mouth then elicits a sweet taste (sweetness-inducing activity). In the present study we systematically examined the properties of the sweet and sweetness-inducing activities of strogins. Strogins 1, 2 and 4 had both the sweet and sweetness-inducing activities, while strogins 3 and 5 had no activities. The sweetness-inducing activity in response to cold water lasted for 1 h for strogin 2 and 2 h for strogins 1 and 4. The sweetness-inducing activity was immediately diminished by application of gamma-cyclodextrin to the mouth after strogins were held in the mouth. It seems that the strogins were adsorbed on the gustatory receptor membranes and eliminated by inclusion activity of gamma-cyclodextrin. The structure of strogin resembles that of gymnemic acid, which has antisweet activity. There was competition between strogin 1 and gymnemic acid; treatment of the tongue with strogin 1 before application of Gymnema extract to the mouth reduced the an...Continue Reading

Citations

May 5, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·A AhamedT Amakawa
Sep 22, 2017·Chemical Society Reviews·Tomáš Pluskal, Jing-Ke Weng
Sep 12, 2017·Beilstein Journal of Nanotechnology·Ana I RamosArtur M S Silva

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