Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in Drosophila

Current Biology : CB
Wolf HuetterothScott Waddell

Abstract

Dopaminergic neurons provide reward learning signals in mammals and insects [1-4]. Recent work in Drosophila has demonstrated that water-reinforcing dopaminergic neurons are different to those for nutritious sugars [5]. Here, we tested whether the sweet taste and nutrient properties of sugar reinforcement further subdivide the fly reward system. We found that dopaminergic neurons expressing the OAMB octopamine receptor [6] specifically convey the short-term reinforcing effects of sweet taste [4]. These dopaminergic neurons project to the β'2 and γ4 regions of the mushroom body lobes. In contrast, nutrient-dependent long-term memory requires different dopaminergic neurons that project to the γ5b regions, and it can be artificially reinforced by those projecting to the β lobe and adjacent α1 region. Surprisingly, whereas artificial implantation and expression of short-term memory occur in satiated flies, formation and expression of artificial long-term memory require flies to be hungry. These studies suggest that short-term and long-term sugar memories have different physiological constraints. They also demonstrate further functional heterogeneity within the rewarding dopaminergic neuron population.

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Citations

Feb 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jackson J ConeMitchell F Roitman
Feb 16, 2016·Current Biology : CB·Astrid RohwedderAndreas S Thum
Feb 10, 2016·Current Biology : CB·Scott Waddell
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Methods Mentioned

BETA
transgenic

Software Mentioned

GraphPad
InSITE
AMIRA
PRISM
Fiji
DenMark

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