Sweet/Fat Preference Taste in Subjects Who are Lean, Obese and Very Obese.

Pharmaceutical Research
Jennifer Leohr, Maria C Kjellsson

Abstract

This study assessed the perception of sweetness, creaminess, and pleasantness from a sweet/fat preference test in subjects who are lean (BMI: 19-25), obese (BMI: 30-33) or very obese (BMI: 34-40) using categorical modeling. Subjects tasted 16 dairy solutions consisting of 0%, 3.5%, 11.3% and 37.5% fat and each containing 0%, 5%, 10%, or 20% sugar and rated them for sweetness, creaminess and pleasantness. A proportional odds model described the perception of sweetness using an Emax for the effect of sugar and a linear effect for fat. Perception of creaminess was dependent on the fat and sugar content and was described with proportional odds model with linear effects of sugar and fat. Perception of pleasantness increased with sugar and fat but decreased in solutions containing 37.5% fat. A differential odds model using an Emax model for fat and sugar with a negative interaction between them allowed the sugar content to be less than proportional and the fat content to be greater than proportional for pleasantness. Application of modeling provided understanding of these complex interactions of sugar and fat on the perception of sweetness, creaminess, and pleasantness and provides a tool to investigate obesity and pharmacological in...Continue Reading

References

Apr 1, 1991·The American Journal of Clinical Nutrition·D J Mela, D A Sacchetti
Jan 1, 1989·Physiology & Behavior·A DrewnowskiM R Greenwood
Oct 1, 1985·Physiology & Behavior·A DrewnowskiM R Greenwood
Feb 14, 1983·Life Sciences·A S Levine, J E Morley
Apr 1, 1983·Physiology & Behavior·A Drewnowski, M R Greenwood
Mar 1, 1983·Appetite·E Trenchard, T Silverstone
Jul 1, 1982·The Journal of Clinical Endocrinology and Metabolism·R L Atkinson
Mar 19, 1982·Science·A MandenoffD L Margules
Sep 1, 1994·Clinical Pharmacology and Therapeutics·L B Sheiner
Dec 1, 1996·Clinical Pharmacology and Therapeutics·J W Mandema, D R Stanski
Jan 1, 1997·Annual Review of Nutrition·A Drewnowski
Apr 9, 1999·Computer Methods and Programs in Biomedicine·E N Jonsson, M O Karlsson
May 16, 2002·Clinical Pharmacology and Therapeutics·Diane R MouldGraham Ross
Feb 27, 2004·The American Journal of Clinical Nutrition·Arline D SalbeP Antonio Tataranni
Jun 24, 2004·Computer Methods and Programs in Biomedicine·Lars LindbomE Niclas Jonsson
Aug 19, 2006·QJM : Monthly Journal of the Association of Physicians·S D H Malnick, H Knobler
Jun 10, 2008·Physiology & Behavior·John E Hayes, Valerie B Duffy
Sep 24, 2008·Journal of Pharmacokinetics and Pharmacodynamics·Maria C KjellssonMats O Karlsson
Oct 18, 2011·Current Drug Abuse Reviews·Ashley N GearhardtKelly D Brownell
Dec 3, 2011·Journal of Food Science·Sara CiceraleRussell S J Keast
Jul 28, 2013·CPT: Pharmacometrics & Systems Pharmacology·K E KarlssonM O Karlsson
Sep 30, 2014·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·I García-GarcíaJ Neumann
Sep 30, 2017·British Journal of Clinical Pharmacology·Linda G FrankenRon A A Mathot
Apr 24, 2018·Journal of Pharmacokinetics and Pharmacodynamics·Matthew L FidlerRamesh Sarangapani
Aug 21, 2019·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·A RoefsA Jansen
Jan 8, 2020·Journal of Pharmacokinetics and Pharmacodynamics·Clémence Rigaux, Bernard Sébastien

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NONMEM ( PsN
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