Swelling of the Golgi apparatus and decrease of galactosyltransferase in polyamine-deficient bovine lymphocytes and epithelium of mouse small intestine

Biochemical Pharmacology
Y SakamakiK Igarashi

Abstract

When bovine small lymphocytes stimulated by concanavalin A were treated with inhibitors (alpha-difluoromethylornithine (5 mM) and ethylglyoxal bis(guanylhydrazone) (100 microM)] of polyamine biosynthesis, swelling of the Golgi apparatus was observed. This was accompanied by decreases in the amount of the Golgi apparatus and of the specific activity of galactosyltransferase. Both spermidine and spermine, at physiological concentrations, stimulated galactosyltransferase activity 2-3-fold. When mice were treated with these inhibitors, the following changes were observed in the epithelial cells of small intestine: swelling of the Golgi apparatus; decrease in the amount of the Golgi apparatus; and decrease of galactosyltransferase activity.

References

Oct 1, 1985·Archives of Biochemistry and Biophysics·R OhnishiK Igarashi
Nov 15, 1987·Archives of Biochemistry and Biophysics·Y KakinumaK Igarashi
Sep 15, 1988·European Journal of Biochemistry·Y KakinumaK Igarashi
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Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S M OredssonL J Marton
Nov 30, 1981·Biochemical and Biophysical Research Communications·K IgarashiS Hirose

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Citations

Nov 12, 2005·Parasitology Research·D MenezesM A Vannier-Santos
Mar 1, 1995·The American Journal of Clinical Nutrition·M C Neville, C T Walsh
Mar 2, 2010·Experimental Cell Research·Kristiina KanervaLeif C Andersson
Feb 8, 2003·The Journal of Biological Chemistry·Ramesh M RayLeonard R Johnson

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