Swept-sine noise-induced damage as a hearing loss model for preclinical assays

Frontiers in Aging Neuroscience
Lorena SanzCarlos Avendaño

Abstract

Mouse models are key tools for studying cochlear alterations in noise-induced hearing loss (NIHL) and for evaluating new therapies. Stimuli used to induce deafness in mice are usually white and octave band noises that include very low frequencies, considering the large mouse auditory range. We designed different sound stimuli, enriched in frequencies up to 20 kHz ("violet" noises) to examine their impact on hearing thresholds and cochlear cytoarchitecture after short exposure. In addition, we developed a cytocochleogram to quantitatively assess the ensuing structural degeneration and its functional correlation. Finally, we used this mouse model and cochleogram procedure to evaluate the potential therapeutic effect of transforming growth factor β1 (TGF-β1) inhibitors P17 and P144 on NIHL. CBA mice were exposed to violet swept-sine noise (VS) with different frequency ranges (2-20 or 9-13 kHz) and levels (105 or 120 dB SPL) for 30 min. Mice were evaluated by auditory brainstem response (ABR) and otoacoustic emission tests prior to and 2, 14 and 28 days after noise exposure. Cochlear pathology was assessed with gross histology; hair cell number was estimated by a stereological counting method. Our results indicate that functional a...Continue Reading

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Citations

May 16, 2015·Cellular and Molecular Life Sciences : CMLS·Rocío de Iriarte RodríguezIsabel Varela-Nieto
Aug 4, 2015·Frontiers in Aging Neuroscience·Marta MagariñosIsabel Varela-Nieto
Apr 9, 2015·Frontiers in Aging Neuroscience·Silvia Murillo-CuestaIsabel Varela-Nieto
Nov 13, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·So Young JungHeebeom Koo

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Methods Mentioned

BETA
light microscopy
dissection

Software Mentioned

CorelDRAW X3
SPSS
Wavelab Lite
CAST

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