Swept-Source OCT Angiography of Serpiginous Choroiditis

Ophthalmology Retina
Kaivon Pakzad-VaeziKathryn L Pepple

Abstract

To examine and quantify choriocapillaris lesions in active and quiescent serpiginous choroiditis (SC) using swept-source optical coherence tomography angiography (SS-OCTA) and en-face image analysis. Prospective observational case series. Patients with a clinical diagnosis of SC. A SS-OCTA prototype was used to image active and quiescent serpiginous lesions longitudinally before and after anti-inflammatory treatment. En-face slabs of choriocapillaris flow (CC-slab) or outer nuclear layer structure (ONL-slab) were generated from OCTA and OCT data, respectively. Qualitative and quantitative analyses on lesion boundary and area using a semi-automated MATLAB algorithm. Lesions were also compared to traditional multimodal imaging. Six eyes of three patients were imaged. Choroidal lesions were identified and analyzed in four of six eyes. Lesions with well-defined boundaries were identified in the CC-slab in areas of both active and inactive choroiditis. CC-slab lesion size and shape showed good correlation with lesions identified on indocyanine green angiography. CC-slab lesion area increased with disease activity and decreased with corticosteroid treatment. During active disease, the CC-slab lesion area was larger than both the ONL-...Continue Reading

Citations

Nov 22, 2019·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Dominika PohlmannUwe Pleyer
May 30, 2019·Journal of Ophthalmic Inflammation and Infection·Vita L S DingerkusMatthias Becker
Aug 19, 2020·Ocular Immunology and Inflammation·Hashim Ali KhanAsim Mehmood
Apr 11, 2020·Expert Review of Medical Devices·Jayesh ViraAniruddha Agarwal
Aug 18, 2020·Case Reports in Ophthalmological Medicine·Carl S WilkinsStephanie Llop
Sep 26, 2020·Ocular Immunology and Inflammation·Aniruddha AgarwalVishali Gupta
Jan 21, 2021·The British Journal of Ophthalmology·Alessandro MarcheseGiuseppe Casalino
Feb 9, 2021·American Journal of Ophthalmology Case Reports·Gayathri C TummalaKathryn L Pepple
Feb 23, 2021·Ocular Immunology and Inflammation·Céline Mebsout-PalladoMarie-Hélène Errera
Mar 13, 2021·Current Opinion in Ophthalmology·Akshay S Thomas, Phoebe Lin
Jun 10, 2021·American Journal of Ophthalmology·K Matthew McKayKathryn L Pepple
Jun 29, 2021·European Journal of Ophthalmology·Manpreet BrarMangat Ram Dogra
Sep 17, 2021·Journal of Ophthalmic Inflammation and Infection·Ilaria TestiCarlos Pavesio

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