PMID: 9529390May 16, 1998Paper

Swi5 controls a novel wave of cyclin synthesis in late mitosis

Molecular Biology of the Cell
B L AerneL H Johnston

Abstract

We have shown previously that the Swi5 transcription factor regulates the expression of the SIC1 Cdk inhibitor in late mitosis. This suggests that Swi5 might control other genes with roles in ending mitosis. We identified a gene with a Swi5-binding site in the promoter that encoded a protein with high homology to Pcl2, a cyclin-like protein that associates with the Cdk Pho85. This gene, PCL9, is indeed regulated by Swi5 in late M phase, the only cyclin known to be expressed at this point in the cell cycle. The Pcl9 protein is associated with a Pho85-dependent protein kinase activity, and the protein is unstable with peak levels occurring in late M phase. PCL2 is already known to be expressed in late G1 and we find that, in addition, it is also regulated by Swi5 in telophase. The expression of PCL2 and PCL9 at this stage of the cell cycle implies a role for the Pho85 Cdk at the end of mitosis. Consistent with this a synthetic interaction was observed between pho85delta and strains deleted for SIC1, SWI5, and SPO12. These and other studies support the notion that the M/G1 switch is a major cell cycle transition.

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Citations

Jul 15, 1999·Computers & Chemistry·M Q Zhang
Apr 1, 1998·Trends in Genetics : TIG·B Andrews, V Measday
Feb 20, 2002·Trends in Biochemical Sciences·Adam S Carroll, Erin K O'Shea
Sep 12, 2006·Nature Structural & Molecular Biology·Robert WysockiStephen J Kron
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Apr 1, 2003·The Journal of Biological Chemistry·Ziyin Li, Ching C Wang
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May 31, 2018·NPJ Systems Biology and Applications·Aouefa AmoussouviEdda Klipp

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