Swietenine extracted from Swietenia relieves myocardial hypertrophy induced by isoprenaline in mice

Environmental Toxicology
Jingjing DingFeng Chen

Abstract

As a traditional plant medicine in tropical areas, Swietenia macrophylla seeds are usually applied for some chronic diseases, including hypertension, diabetes, and so on. Few studies have been carried out to identify the effective elements in seed extract and their indications. In this study, we first investigated the functions of the swietenine, an extract from S. macrophylla seeds, using a model of myocardial hypertrophy induced by isoprenaline (ISO). At cellular level, H9c2 cell hypertrophy was also established through the treatment with ISO. The cardiac pathological remodeling was evaluated by echocardiography and histological analysis. Western blot and RT-qPCR were used to detect the expression of possible hypertrophy-promoting genes. Here, our results indicated that swietenine remarkably attenuated ISO-induced myocardial hypertrophy in vivo and in vitro. Moreover, Akt phosphorylation, ANP and BNP mRNA expression were efficiently decreased. Based on these findings, we concluded that swietenine might be a promising anti-hypertrophic agent against cardiac hypertrophy.

References

Aug 29, 2006·Nature Reviews. Molecular Cell Biology·Joerg Heineke, Jeffery D Molkentin
Feb 6, 2007·Biochemical and Biophysical Research Communications·Satomi KatoKeyong Du
Mar 28, 2008·The New England Journal of Medicine·Joseph A Hill, Eric N Olson
Feb 26, 2009·Fitoterapia·Saikat DewanjeeSankar P Dey
Nov 18, 2010·In Vitro Cellular & Developmental Biology. Animal·Sarah J WatkinsHelen M Arthur
Jan 19, 2012·European Journal of Heart Failure·Hossein ArdehaliMihai Gheorghiade
Apr 3, 2012·International Journal of Cardiology·Rishi K SomvanshiUjendra Kumar
Jun 12, 2013·Journal of the American College of Cardiology·Xinli LiUNKNOWN Efficacy and Safety of Qili Qiangxin Capsules for Chronic Heart Failure Study Group
Apr 11, 2015·Circulation Research·Robert C LyonFarah Sheikh
May 31, 2015·Vascular Pharmacology·Prasanna Abeyrathna, Yunchao Su
Jun 6, 2016·Journal of Molecular and Cellular Cardiology·Ippei Shimizu, Tohru Minamino
Jul 5, 2017·The Journal of Physiological Sciences : JPS·Ali KhalilimeybodiBabak Sharif-Kashani
Aug 25, 2017·Nature Reviews. Disease Primers·Michelle W BloomJaved Butler
Apr 21, 2018·Nature Reviews. Cardiology·Michinari Nakamura, Junichi Sadoshima
Jun 4, 2018·Peptides·Yasuaki NakagawaKoichiro Kuwahara
Oct 17, 2018·Journal of Dietary Supplements·Suchitra K PanigrahyRenu Bhatt
Nov 23, 2018·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Jia FanJuejin Wang
May 14, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Congping SuWei Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.