Swift Intrahepatic Accumulation of Granulocytic Myeloid-Derived Suppressor Cells in a Humanized Mouse Model of Toxic Shock Syndrome

The Journal of Infectious Diseases
Peter A SzaboS M Mansour Haeryfar

Abstract

Toxic shock syndrome (TSS) and other superantigen-mediated illnesses are associated with 'systemic' immunosuppression that jeopardizes the host's ability to fight pathogens. Here, we define a novel mechanism of 'local' immunosuppression that may benefit the host. Systemic exposure to staphylococcal enterotoxin B (SEB) rapidly and selectively recruited CD11b(+)Gr-1(high)Ly-6C(+) granulocytic myeloid-derived suppressor cells (MDSCs) to the liver of HLA-DR4 transgenic mice. Hepatic MDSCs inhibited SEB-triggered T cell proliferation in a reactive oxygen species-dependent manner, and ex vivo-generated human MDSCs also similarly attenuated the proliferative response of autologous T cells to SEB. We propose a role for MDSCs in mitigating excessive tissue injury during TSS.

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Nov 2, 2011·Immunology and Cell Biology·Jacqueline L HayworthS M Mansour Haeryfar

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Citations

Feb 22, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter A SzaboS M Mansour Haeryfar
Nov 13, 2018·The Journal of Infectious Diseases·Courtney E MeilleurS M Mansour Haeryfar
May 31, 2018·Pathogens·Stephen W TuffsJohn K McCormick
Oct 3, 2018·Frontiers in Cellular and Infection Microbiology·Hartmut StollNikolaus Rieber
May 20, 2017·Frontiers in Immunology·Dane Parker
Mar 7, 2021·International Journal of Molecular Sciences·Krzysztof Laudanski

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