Swim Training Modulates Skeletal Muscle Energy Metabolism, Oxidative Stress, and Mitochondrial Cholesterol Content in Amyotrophic Lateral Sclerosis Mice

Oxidative Medicine and Cellular Longevity
D J FlisWieslaw Ziolkowski

Abstract

Recently, in terms of amyotrophic lateral sclerosis (ALS), much attention has been paid to the cell structures formed by the mitochondria and the endoplasmic reticulum membranes (MAMs) that are involved in the regulation of Ca2+ signaling, mitochondrial bioenergetics, apoptosis, and oxidative stress. We assumed that remodeling of these structures via swim training may accompany the prolongation of the ALS lifespan. In the present study, we used transgenic mice with the G93A hmSOD1 gene mutation. We examined muscle energy metabolism, oxidative stress parameters, and markers of MAMs (Caveolin-1 protein level and cholesterol content in crude mitochondrial fraction) in groups of mice divided according to disease progression and training status. The progression of ALS was related to the lowering of Caveolin-1 protein levels and the accumulation of cholesterol in a crude mitochondrial fraction. These changes were associated with aerobic and anaerobic energy metabolism dysfunction and higher oxidative stress. Our data indicated that swim training prolonged the lifespan of ALS mice with accompanying changes in MAM components. Swim training also maintained mitochondrial function and lowered oxidative stress. These data suggest that modi...Continue Reading

References

Jan 1, 1984·Methods in Enzymology·H Aebi
Apr 29, 1998·Journal of the Neurological Sciences·F R WiedemannW S Kunz
Feb 14, 2002·Journal of Neurochemistry·Falk R WiedemannEric A Schon
Dec 6, 2003·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·J Iłzecka, Z Stelmasiak
May 20, 2005·Brain : a Journal of Neurology·Anna KrasnianskiStephan Zierz
Sep 24, 2005·Annals of Neurology·M Flint Beal
Feb 14, 2006·Current Neurology and Neuroscience Reports·Peter M Andersen
Apr 4, 2006·Muscle & Nerve·Douglas J MahoneyMark A Tarnopolsky
May 23, 2006·Biochimica Et Biophysica Acta·Siân C BarberPamela J Shaw
Oct 4, 2006·Journal of Pineal Research·Jochen H WeishauptHannelore Ehrenreich
Jun 23, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Florian L MullerHolly Van Remmen
Dec 3, 2008·Cell Metabolism·Gabriella DobrowolnyAntonio Musarò
Jun 6, 2009·The Journal of Physiology·Séverine DeforgesFrédéric Charbonnier
Nov 26, 2010·Journal of Neurology·Francisco Javier Miana-MenaJoaquín José García
Apr 8, 2011·Current Alzheimer Research·P H Reddy, T P Reddy
Jul 6, 2011·The Biochemical Journal·Martin D Brand, David G Nicholls
Dec 22, 2011·Biochemical and Biophysical Research Communications·Michiko FujimotoTsung-Ping Su
May 16, 2012·The Journal of Physiology·Steen LarsenMartin Hey-Mogensen
Jul 19, 2012·Communicative & Integrative Biology·Maurizio SoriceWalter Malorni
Jun 5, 2013·Experimental Physiology·Wieslaw ZiolkowskiRosita Gabbianelli
Jun 16, 2015·Free Radical Biology & Medicine·Betul KarademirNesrin Kartal Ozer
Aug 19, 2015·Neurobiology of Disease·Giovanni Manfredi, Hibiki Kawamata
Sep 18, 2015·Frontiers in Cellular Neuroscience·Francesco TafuriStefania Corti
Nov 20, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tara Z BarisMarjorie F Oleksiak
Feb 24, 2016·Trends in Neurosciences·Sebastien PaillussonChristopher C J Miller

❮ Previous
Next ❯

Citations

May 30, 2020·Experimental Physiology·Bilal A MirVictoria C Foletta
Dec 5, 2019·International Neurourology Journal·Dae-Yun SeoHyo-Bum Kwak
Mar 3, 2019·International Journal of Molecular Sciences·Igor I Krivoi, Alexey M Petrov
Apr 6, 2019·Frontiers in Neuroscience·Malgorzata Halon-GolabekJedrzej Antosiewicz
Nov 17, 2020·Oxidative Medicine and Cellular Longevity·Xiaoyu WangAnwen Shao
Dec 20, 2020·International Journal of Molecular Sciences·Yi Sun, Shuzhe Ding
Mar 23, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Alejandro Silva-PalaciosJosé Pedraza-Chaverri
Feb 28, 2021·Mitochondrion·Rishabh JhanjiSimona Bungau
Apr 4, 2021·Cells·Silvia ScaricamazzaCristiana Valle
May 14, 2021·Molecular Therapy. Methods & Clinical Development·Shanshan WangBrian P Head

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
Assay
ELISA
PCA

Software Mentioned

R
Statistica

Related Concepts

Related Feeds

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Caveolins & Signal Transduction

Caveolins are small proteins with a hairpin loop conformation that are located in the plasma membrane of various cell types where they bind cholesterol and interact with receptors essential for several signal transduction pathways. Here is the latest research.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.