PMID: 39309Jun 21, 1979

Swimming capacity of mice after prolonged treatment with psychostimulants. III. Effect of fencamfamine on swimming endurance and availability of metabolic substrates

Psychopharmacology
C J Estler, M K Gabrys

Abstract

The effect of long-term treatment with fencamfamine on swimming endurance and availability of metabolic substrates was investigated in mice. Fencamfamine (14 micrograms/g per day orally for 6 weeks) reduced maximum swimming capacity by more than 40%. This effect could not be attributed to motor incoordination or a diminution of pre-swimming levels of metabolic substrates such as liver and muscle glycogen or blood glucose and non-esterfied fatty acids. However, during swimming the hepatic and muscular glycogen stores were depleted more rapidly in the fencamfamine-treated animals. Thus it appears that fencamfamine leads more rapidly to a shortage of combustible substrates in the swimming animals.

References

Sep 1, 1985·Pharmacology, Biochemistry, and Behavior·M E RisnerE J Cone
Jan 1, 1989·Acta Oncologica·G De Palo

Related Concepts

Metabolic Process, Cellular
Swimming
Fat Pad
Norbornanes
Hepatic
Liver Glycogen
Abnormal Coordination
Muscle
Blood Glucose Measurement
Psychostimulant

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