Swimming exercise prevents behavioural disturbances induced by an intracerebroventricular injection of amyloid-β1-42 peptide through modulation of cytokine/NF-kappaB pathway and indoleamine-2,3-dioxygenase in mouse brain

Behavioural Brain Research
Leandro C SouzaSilvana Peterini Boeira

Abstract

Emerging evidence indicates that the activation of indoleamine-2,3-dioxygenase (IDO), a first and rate-limiting enzyme in the kynurenine (KYN) pathway, is involved in amyloid-beta (Aβ1-42)-neurotoxicity and Alzheimer's disease (AD) pathogenesis. Physical exercise has been considered an effective intervention in AD, attenuating or limiting their progression. Nevertheless, the neurobiological mechanisms underlying the neuroprotective effects of exercise have not yet been fully elucidated. In present study, we investigated the protective effect of an 8-week swimming training (ST) exercise on cognitive and non-cognitive functions and its role in modulating biomarkers of KYN pathway, before an intracerebroventricular (i.c.v.) injection of Aβ1-42 (400pmol/animal; 3μl/site) peptide in mice. Our results demonstrated that ST was effective in preventing the following behavioural disturbances caused by Aβ1-42 injection: memory impairment in the object recognition test and depressive/anxiety-like behaviour in the tail suspension test and elevated plus-maze test, respectively. ST abrogated the neuroinflammatory response and neurotrophic deficiency in the prefrontal cortex and hippocampus induced by Aβ1-42. Also, Aβ1-42 increased IDO activit...Continue Reading

References

Jul 20, 2010·Advances in Medical Sciences·E GulajD Pawlak

❮ Previous
Next ❯

Citations

Feb 27, 2018·The Physician and Sportsmedicine·Paul D LoprinziPamela Ponce
Jan 16, 2020·Molecular Medicine Reports·Xiaopeng Wang, Jing Zhao
Sep 27, 2018·Journal of Neuroinflammation·Estella A NewcombeRodrigo Medeiros
May 16, 2019·Neurotoxicity Research·Michelle L GarcezGilles J Guillemin
May 4, 2020·Progress in Neurobiology·Michel MaitreAyikoe-Guy Mensah-Nyagan
Apr 23, 2021·Journal of Hematology & Oncology·Kai TangBin Yu
May 5, 2021·Physiology & Behavior·Parinaz MatinfarMohammad Ali Azarbayjani
May 6, 2021·Acta Neurobiologiae Experimentalis·Rodrigo Freire OliveiraJosé Rodolfo Lopes de Paiva Cavalcanti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.