Swine hemi-facial composite tissue allotransplantation: a model to study immune rejection

The Journal of Surgical Research
Yur-Ren KuoW P Andrew Lee

Abstract

Partial face composite tissue allotransplantation was recently achieved in a human subject. However, the side effects of long-term immunosuppression and chronic rejection area still need concerning. This preliminary study investigated the reproducibility of swine hemi-facial transplantation for preclinical studies. Eleven out-bred miniature swine underwent hemi-facial transplant. The hemi-facial orthotopic transplant consisted of ear cartilage, auricular nerve, parotid gland and lymphoid tissue, muscle with surrounding hemi-facial skin paddle supplied by the carotid artery, and external jugular vein transplanted to recipient swine. Three different experimental designs were studied, as follows: group I (n = 4): autologous hemi-facial transplantation as a normal control; group II (n = 4): hemi-facial allotransplantation without treatment; group III (n = 3): hemi-facial allotransplantation with cyclosporine-A treatment for 4 wk. The transplanted face was observed daily for signs of rejection. Biopsy of donor skin, gland lymphoid tissue, and cartilage were obtained at specified predetermined time (d 7, 14, 28), or at the time of clinically evident rejection. The results indicated the survival of group I following autologous hemi-fa...Continue Reading

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Citations

Nov 2, 2012·Transplantation·David A LeonardDavid H Sachs
Dec 12, 2012·Clinical & Developmental Immunology·Yur-Ren KuoChao-Long Chen
Feb 14, 2009·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·K KnoblochP M Vogt
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Sep 2, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Maria Siemionow, Aleksandra Klimczak
Aug 21, 2014·Acta Cirúrgica Brasileira·Fábio de Freitas BusnardoRolf Gemperli
Mar 13, 2014·Annals of Plastic Surgery·Safak UygurMaria Siemionow
Mar 29, 2019·The Journal of Craniofacial Surgery·Ithalo Queiroz RodriguesRenato da Silva Freitas
May 10, 2016·The Journal of Craniofacial Surgery·Caroline CunicoRenato da Silva Freitas

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