SWI/SNF: a chromatin-remodelling complex with a role in carcinogenesis

The International Journal of Biochemistry & Cell Biology
Gary M HallidayJ Guy Lyons

Abstract

SWI/SNF is a chromatin-remodelling complex that makes DNA that has been compacted into nucleosomes accessible to transcription factors and repair enzymes. It does this by displacing DNA from the core histone surface. SWI/SNF consists of at least nine subunits, including one of two alternative ATPase subunits, BRM or BRG-1, that provide the energy for remodelling. As it regulates access to DNA it controls many aspects of normal cellular function. Limited studies have recently linked loss of function of SWI/SNF subunits to cancer development, suggesting that it may be a tumor suppressor complex. As epigenetic repression regulates SWI/SNF component expression at least in some cases, restoration of function is therapeutically promising for cancer treatment. Considerably more research is required into deregulation of SWI/SNF in cancer and determination of how this affects tumor development. This is an exciting but poorly understood molecule that may have a role in carcinogenesis.

References

May 1, 1981·Genetics·M CarlsonD Botstein
May 14, 1999·Current Opinion in Genetics & Development·S Jacobson, L Pillus
Sep 25, 2003·Biochemical Society Transactions·T Owen-Hughes
Mar 9, 2004·Trends in Biochemical Sciences·Vasily M StuditskyGary Felsenfeld
Apr 3, 2004·Molecular and Cellular Biology·Kevin W Trotter, Trevor K Archer
Dec 9, 2004·International Journal of Oncology·Esra GunduzNoriyuki Nagai
Sep 13, 2005·Journal of Cellular Physiology·Cristiano Simone
Dec 13, 2005·Nature Structural & Molecular Biology·Eric BatschéChristian Muchardt
Mar 7, 2006·Nature Structural & Molecular Biology·Martin ZofallBlaine Bartholomew
Jun 14, 2006·The Journal of Biological Chemistry·Juana M García-PedreroBorja Belandia
Feb 13, 2007·Mutation Research·Mary Ann OsleyJac A Nickoloff
Jul 20, 2007·Oncogene·S J BultmanT Magnuson

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Citations

Mar 26, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Oluwole FadareVinita Parkash
Dec 23, 2009·Hybridoma·Seiji OkadaYasuyuki Ohkawa
Feb 27, 2010·Journal of Pediatric Hematology/oncology·John A D'Orazio
May 25, 2010·Photochemistry and Photobiology·Joohong ParkDiona L Damian
Oct 22, 2009·Cancer Research·Bernard Weissman, Karen E Knudsen
Jan 25, 2011·The Journal of Urology·Katia R M LeiteMiguel Srougi
Dec 1, 2010·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Changxin MaWei Wu
Jan 20, 2010·Biochemical and Biophysical Research Communications·Jiri VachtenheimJan Borovanský
Jun 22, 2012·Journal of Cellular Physiology·Francesco Paolo FiorentinoAntonio Giordano
Dec 1, 2009·Bio Systems·Amin R MazloomSajal K Das
Nov 15, 2014·Electrophoresis·Verena PaulitschkeRainer Kunstfeld
Jun 20, 2018·The Journal of Physiology·Cheng-Jun HuKurt R Stenmark
May 28, 2010·Journal of Cellular Physiology·Rachit BakshiGary S Stein
Aug 20, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Keerakarn SomsuanVisith Thongboonkerd
Dec 21, 2017·Skin Pharmacology and Physiology·Ana R FernandesEliana B Souto
Jun 23, 2015·Oncoscience·Kenneth W ThompsonDavid Reisman
Jul 11, 2012·Experimental Dermatology·Gary M HallidayJ Guy Lyons
Nov 13, 2019·Biochemical Genetics·Jadwiga GaździckaZofia Ostrowska

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