SwissPalm: Protein Palmitoylation database

F1000Research
Mathieu BlancFrançoise Gisou van der Goot

Abstract

Protein S-palmitoylation is a reversible post-translational modification that regulates many key biological processes, although the full extent and functions of protein S-palmitoylation remain largely unexplored. Recent developments of new chemical methods have allowed the establishment of palmitoyl-proteomes of a variety of cell lines and tissues from different species.  As the amount of information generated by these high-throughput studies is increasing, the field requires centralization and comparison of this information. Here we present SwissPalm ( http://swisspalm.epfl.ch), our open, comprehensive, manually curated resource to study protein S-palmitoylation. It currently encompasses more than 5000 S-palmitoylated protein hits from seven species, and contains more than 500 specific sites of S-palmitoylation. SwissPalm also provides curated information and filters that increase the confidence in true positive hits, and integrates predictions of S-palmitoylated cysteine scores, orthologs and isoform multiple alignments. Systems analysis of the palmitoyl-proteome screens indicate that 10% or more of the human proteome is susceptible to S-palmitoylation. Moreover, ontology and pathway analyses of the human palmitoyl-proteome r...Continue Reading

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Methods Mentioned

BETA
GTPases
ubiquitination
immunoprecipitation
targeted

Key Resources (RRID) Mentioned

AB_10864216
AB_10565196
AB_2073761
AB_11154964
AB_628423
AB_1675188

Software Mentioned

STRING
R
Palm
SwissPalm
Sample Logo
RCytoscape
PalmPred
MAFFT
Two
TrEMBL

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