Switch of K+ buffering conditions in rabbit retinal Müller glial cells during postnatal development

Neuroscience Letters
Stefan SchopfSerguei N Skatchkov

Abstract

Although spatial buffering of excess extracellular K+ by K+ channels is a main function of retinal glial (Müller) cells, there are severe limitations to long distance K+-spatial buffering that have been predicted for (immature) glial cells: (i) a lack of inwardly rectifying K+ (Kir) channels [Glia 21(1997) 46]; and (ii) high internal resistance of outgrowing (cable like) processes [W. Rall, Handbook of Physiology, Section 1, vol. 1, Part 1, American Physiological Society, Bethesda, 1977, pp. 39-97]. In order to determine if changes in developing Müller cells improve or worsen their capability of carrying K+ spatial buffering currents, we compared the whole-cell currents of acutely isolated Müller cells at 5, 11 and 28 postnatal days of rabbits. Both K+-spatial buffer limitations described above were found in early postnatal stage (5 days), however, the cells overcome these limitations shortly after 11 days. During the period of 11-28 days, rabbit Müller cells simultaneously increase stalk axial conductance and express Kir channels. Both processes take place during the critical stage of retinal maturation, and should dramatically improve "cable" K+-spatial buffering.

References

Oct 1, 1977·The Journal of Comparative Neurology·R H Masland
Sep 1, 1991·The Journal of Comparative Neurology·A ReichenbachA Henke
Nov 11, 1986·Neuroscience Letters·A Reichenbach, W Reichelt
Jan 1, 1994·Pflügers Archiv : European journal of physiology·T I ChaoA Reichenbach
Aug 1, 1996·Trends in Neurosciences·E Newman, A Reichenbach
Sep 23, 1997·Glia·T AmédéeJ A Coles
Jul 1, 1997·Journal of Neurocytology·T I ChaoA Reichenbach
Aug 24, 1999·The European Journal of Neuroscience·A BringmannA Reichenbach
Apr 13, 2004·Neuroreport·Misty J EatonSerguei N Skatchkov

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Citations

Feb 23, 2008·Glia·Yuriy V KucheryavykhSerguei N Skatchkov
Feb 19, 2020·Molecular Membrane Biology·Jia LiuWei Zou

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