Switching bonds in a DNA gel: an all-DNA vitrimer

Physical Review Letters
Flavio Romano, Francesco Sciortino

Abstract

We design an all-DNA system that behaves like vitrimers, innovative plastics with self-healing and stress-releasing properties. The DNA sequences are engineered to self-assemble first into tetra- and bifunctional units which, upon further cooling, bind to each other forming a fully bonded network gel. An innovative design of the binding regions of the DNA sequences, exploiting a double toehold-mediated strand displacement, generates a network gel which is able to reshuffle its bonds, retaining at all times full bonding. As in vitrimers, the rate of bond switching can be controlled via a thermally activated catalyst, which in the present design is very short DNA strands.

References

Aug 26, 1998·Nature·E WinfreeN C Seeman
Jan 24, 2003·Nature·Nadrian C Seeman
Dec 17, 2004·Journal of the American Chemical Society·Paul W K RothemundErik Winfree
May 16, 2007·Journal of the American Chemical Society·Christoph M ErbenAndrew J Turberfield
Mar 31, 1995·Science·C A Angell
Dec 22, 2009·Nature Nanotechnology·Mathew M MayeOleg Gang
Jul 21, 2010·Journal of Computational Chemistry·Joseph N ZadehNiles A Pierce
Nov 26, 2010·Nature Chemistry·Seung Hyeon KoChengde Mao
Jan 25, 2011·Nature Chemistry·David Yu Zhang, Georg Seelig
Mar 3, 2011·The Journal of Chemical Physics·Thomas E OuldridgeJonathan P K Doye
Nov 18, 2009·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Rosalind J AllenPieter Rein Ten Wolde
Aug 23, 2011·Chemical Society Reviews·Young Hoon RohDan Luo
Nov 19, 2011·Science·Damien MontarnalLudwik Leibler
May 9, 2012·ACS Nano·Xiang LiChengde Mao
May 10, 2012·Journal of the American Chemical Society·Yi-Xuan LuZhibin Guan
Jul 5, 2012·Angewandte Chemie·Chuan ZhangChengde Mao
Oct 9, 2012·The Journal of Chemical Physics·Petr ŠulcArd A Louis
Dec 4, 2012·Nature Nanotechnology·Jong Bum LeeDan Luo
Mar 21, 2009·Soft Matter·Stephen WhitelamPhillip L Geissler
Aug 13, 2013·Nucleic Acids Research·Thomas E OuldridgeArd A Louis
Sep 11, 2013·Nucleic Acids Research·Niranjan SrinivasErik Winfree
Sep 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Silvia BiffiTommaso Bellini
Oct 15, 2013·Physical Chemistry Chemical Physics : PCCP·Jonathan P K DoyeWilliam P J Smith
Nov 19, 2013·Physical Review Letters·Frank SmallenburgFrancesco Sciortino
Mar 22, 2014·ACS Nano·Lorenzo RovigattiFrancesco Sciortino

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Citations

Jan 6, 2016·The Journal of Physical Chemistry. B·Himal BhattSurinder M Sharma
May 2, 2016·The Journal of Chemical Physics·Lorenzo Di MicheleBortolo M Mognetti
Aug 22, 2016·The Journal of Chemical Physics·B A LindquistT M Truskett
Feb 6, 2017·ACS Nano·Emanuele LocatelliLorenzo Rovigatti
Jan 14, 2017·The European Physical Journal. E, Soft Matter·Francesco Sciortino
Jan 1, 2016·Chemical Science·Wim DenissenFilip E Du Prez
Oct 13, 2018·Nanoscale·Clemens JochumChristos N Likos
Feb 14, 2018·Physical Review Letters·Hao HuRan Ni
May 9, 2019·Nanoscale·Francesca BomboiFrancesco Sciortino
Jul 30, 2019·Nanoscale·Supriyo NaskarPrabal K Maiti
Jan 11, 2018·Polymers·Zhenhua WangYan Ji
Jan 10, 2017·Gels·M Joan TaylorTarsem S Sahota
Oct 3, 2019·The Journal of Chemical Physics·Michael P HowardThomas M Truskett
Jan 15, 2018·The Journal of Chemical Physics·J Fernandez-CastanonF Sciortino
Sep 22, 2017·Soft Matter·Miroslav Jurásek, Robert Vácha
May 20, 2021·Physical Review. E·Enrico SkoruppaEnrico Carlon
Feb 5, 2019·Chemical Reviews·Friedrich C SimmelHari R Singh

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