Switching from an originator anti-TNF to a biosimilar in patients with inflammatory bowel disease: Can it be recommended? A systematic review

Gastroenterología y hepatología
Javier P Gisbert, María Chaparro

Abstract

To review the effectiveness and safety of switching from an originator anti-TNF (Remicade®) to a biosimilar (CT-P13) in patients with inflammatory bowel disease (IBD). Electronic and manual search up to September 2017. We identified 24 studies evaluating switching between Remicade® and CT-P13 in 1326 patients. Disease control (no worsening after switching) was confirmed in most of the patients (weighted mean, 88%; 95% CI=86-89%). No unexpected adverse effects were reported in any of the studies. The risks of switching from Remicade® to a biosimilar seem to be purely theoretical and are not supported by the (still limited) real-world clinical practice experience. On the contrary, a steadily increasing number of publications have shown that there seem to be no safety or efficacy concerns about switching. Therefore, switching from originator to biosimilar infliximab in patients with IBD may be considered acceptable.

Citations

May 23, 2019·Alimentary Pharmacology & Therapeutics·Antoine MeyerAlain Weill
Oct 17, 2019·Cadernos de saúde pública·Paula Teixeira Pinto Ferreira NetoMarco Antonio Vargas
Sep 13, 2019·Expert Review of Pharmacoeconomics & Outcomes Research·András HarsányiAndrás Inotai
Jan 24, 2020·Digestive Diseases and Sciences·Edmond-Jean BernardVipul Jairath
Apr 3, 2019·Therapeutic Advances in Chronic Disease·Konstantinos PapamichaelAdam S Cheifetz
Dec 24, 2018·Expert Opinion on Biological Therapy·Mercedes Gimeno-GraciaFernando Gomollón
Apr 28, 2020·Journal of Ophthalmic Inflammation and Infection·Fernanda Nicolela Susanna, Carlos Pavesio
Oct 23, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Stacy Elder DalpoasKenneth M Shermock
Jan 14, 2021·Survey of Ophthalmology·Maram E A Abdalla Elsayed, Igor Kozak
Oct 28, 2021·Drugs·Eduardo MyslerLaurent Peyrin-Biroulet
Dec 18, 2021·Expert Opinion on Biological Therapy·Javier P GisbertGiampiero Girolomoni

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