PMID: 25775727Mar 18, 2015Paper

Switching from high-efficacy lipid-lowering therapies [atorvastatin or rosuvastatin] to simvastatin and the results on low-density lipoprotein cholesterol level

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet

Abstract

In Thai National List of Essential Drugs in 2010, simvastatin is the only medication on the list for the statin group. Patients who previously prescribed other groups of statin were recommended to switch to simvastatin. Comparison of lipid low-density lipoprotein cholesterol (LDL) levels before and after switching from rosuvastatin or atorvastatin to simvastatin. The study was a retrospective observational study performed in patients older than 18 year-old who were enrolled as an outpatient at Siriraj Hospital during October 2009 and October 2010. From these patients who were switched from atorvastatin or rosuvastatin to simvastatin, LDL level was compared between before and after switching to simvastatin. Of 276 patients who were switched from atorvastatin to equivalent dose simvastatin, LDL levels increased from 106.20 ± 33.47 mg/dl to 109.61 ± 39.62 mg/dl (p = 0.089). Of 228 patients who were switched from rosuvastatin to a less than equivalent dose simvastatin, LDL levels increased from 112.73 ± 45.94 mg/dl to 114.49 ± 42.70 mg/dl (p = 0.437). In the patients who were switched from atorvastatin and rosuvastatin to simvastatin, LDL levels before and after being switched was not significantly different. Moreover patients who ...Continue Reading

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.