Switching modes in corticogenesis: mechanisms of neuronal subtype transitions and integration in the cerebral cortex

Frontiers in Neuroscience
Kenichi Toma, Carina Hanashima

Abstract

Information processing in the cerebral cortex requires the activation of diverse neurons across layers and columns, which are established through the coordinated production of distinct neuronal subtypes and their placement along the three-dimensional axis. Over recent years, our knowledge of the regulatory mechanisms of the specification and integration of neuronal subtypes in the cerebral cortex has progressed rapidly. In this review, we address how the unique cytoarchitecture of the neocortex is established from a limited number of progenitors featuring neuronal identity transitions during development. We further illuminate the molecular mechanisms of the subtype-specific integration of these neurons into the cerebral cortex along the radial and tangential axis, and we discuss these key features to exemplify how neocortical circuit formation accomplishes economical connectivity while maintaining plasticity and evolvability to adapt to environmental changes.

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Citations

Nov 18, 2016·The Journal of Endocrinology·Juan Bernal
Dec 17, 2016·Current Opinion in Neurobiology·Anthony M RossiClaude Desplan
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Sep 26, 2019·Cell Death and Differentiation·Siraj K ZahrFreda D Miller
Jun 7, 2017·Proceedings of the National Academy of Sciences of the United States of America·Daniel J DennisCarol Schuurmans
Nov 5, 2019·Frontiers in Molecular Neuroscience·Matías Alvarez-SaavedraDavid J Picketts
May 3, 2020·Development·Saptarshi BiswasDritan Agalliu
Oct 13, 2020·Frontiers in Cell and Developmental Biology·Misato IwashitaYoichi Kosodo
Sep 15, 2020·Thyroid : Official Journal of the American Thyroid Association·Yue LiangWeiping Teng
Aug 11, 2020·Seminars in Cell & Developmental Biology·Danyon HarkinsMichael Piper
Oct 15, 2020·International Journal of Molecular Sciences·Andrea LopesLudovic Telley
Feb 13, 2020·Cell Reports·Caroline Alayne PearsonBennett G Novitch

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Methods Mentioned

BETA
gene knockout

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