Switching of oral bisphosphonates to denosumab in chronic glucocorticoid users: a 12-month randomized controlled trial

Bone
Chi Chiu MokKwok Man Ma

Abstract

To evaluate the effect of switching from oral bisphosphonates to denosumab on bone mineral density (BMD) in long-term glucocorticoid users. Adult patients who were receiving long-term prednisolone (≥2.5 mg/day for ≥1 year) and oral bisphosphonates (≥2 years) were recruited. Participants were randomized to either continue oral bisphosphonates or switch to denosumab (60 mg subcutaneously every 6 months) for 12 months. Serial BMD (lumbar spine, hip) and bone turnover markers (serum osteocalcin, P1NP, β-CTX) were measured. 42 women were recruited (age 54.7±12.9 years; 21 shifted to denosumab and 21 continued on bisphosphonates). The duration of prednisolone therapy was 101±66.3 months and the daily dose was 4.4±2.1 mg. Baseline demographic data, osteoporosis risk factors, and BMD at various sites were similar between the two groups of patients. At month 12, BMD of the spine and hip increased by +3.4±0.9% (p=0.002) and +1.4±0.6% (p=0.03), respectively, in the denosumab group; whereas the corresponding change was +1.5±0.4% (p=0.001) and +0.80±0.5% (p=0.12) in the bisphosphonate group. The spinal BMD at month 12 was significantly higher in the denosumab than bisphosphonate group after adjustment for baseline BMD and β-CTX values, and ...Continue Reading

References

Dec 16, 1998·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A C LookerR Lindsay
Sep 16, 2003·Biochimica Et Biophysica Acta·Chu Chang ChuaRonald C Hamdy
May 9, 2006·Clinical Therapeutics·Fernie J A Penning-van BeestRon M C Herings
Dec 30, 2006·Arthritis and Rheumatism·Frank De VriesTjeerd P Van Staa
Jan 11, 2008·Journal of Cellular Biochemistry·M EijkenJ P T M van Leeuwen
Apr 3, 2008·Current Medical Research and Opinion·Fernie J A Penning-van BeestRon M C Herings
Jul 15, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·David L KendlerHenry G Bone
Feb 4, 2010·Nature Reviews. Rheumatology·Juliet Compston
Jul 2, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Karen E HansenRobert A Adler
Sep 6, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N B WattsS Ferrari
Jan 10, 2013·Current Medical Research and Opinion·Robert JosseMarla Shapiro
Aug 28, 2013·The Journal of Clinical Endocrinology and Metabolism·Henry G BoneSocrates Papapoulos
Feb 11, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E CairoliI Chiodini
Nov 30, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Gregory R Emkey, Sol Epstein

❮ Previous
Next ❯

Citations

Sep 29, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Cuoghi Edens, Angela Byun Robinson
Oct 21, 2016·Expert Opinion on Pharmacotherapy·M C van der GoesJ W Jacobs
Oct 21, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Amy Y SatoTeresita Bellido
Sep 14, 2017·Calcified Tissue International·Irene E M Bultink
Sep 1, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Emory Hsu, Mark Nanes
Jun 8, 2018·Expert Review of Clinical Immunology·Miguel A González-GaySantos Castañeda
Jul 25, 2018·Expert Opinion on Pharmacotherapy·Miguel A González-GaySantos Castañeda
Jul 3, 2018·Clinical Reviews in Bone and Mineral Metabolism·Amy Y SatoTeresita Bellido
May 17, 2019·Expert Review of Endocrinology & Metabolism·Kira Hu, Jonathan D Adachi
Feb 1, 2020·Expert Opinion on Pharmacotherapy·Iacopo ChiodiniLuigi Gennari
Jan 4, 2020·The Journal of Clinical Endocrinology and Metabolism·Talia Diker-CohenAnat Gafter-Gvili
Dec 22, 2017·Cancer·Hiroto InabaSue C Kaste
Jul 19, 2018·Rheumatology International·Ilke Coskun Benlidayi
Dec 9, 2020·Expert Opinion on Drug Safety·Maria V Deligiorgi, Dimitrios T Trafalis
Jan 15, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Natalia Weare-RegalesRichard F Lockey
Apr 3, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Stefano FraraAndrea Giustina
Aug 7, 2021·Zeitschrift für Rheumatologie·Jan LeipeUNKNOWN die Kommission Pharmakotherapie der Deutschen Gesellschaft für Rheumatologie e. V. (DGRh)
Oct 28, 2021·Zeitschrift für Rheumatologie·Jan LeipeKlaus Krüger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
David KendlerHenry G Bone
Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
Michael A BologneseCesar Libanati
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Maurizio RossiniSilvano Adami
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Edward T MiddletonS M Doherty
© 2021 Meta ULC. All rights reserved