Switching Selective Serotonin Reuptake Inhibitors in Adolescents with Selective Serotonin Reuptake Inhibitor-Resistant Major Depressive Disorder: Balancing Tolerability and Efficacy

Journal of Child and Adolescent Psychopharmacology
Jeffrey R StrawnPaul E Croarkin

Abstract

Objective: To guide clinicians in selecting the "next line" selective serotonin reuptake inhibitor (SSRI) for adolescents with treatment-resistant major depressive disorder, we sought to compare response rates among SSRIs in the Treatment of SSRI-Resistant Depression in Adolescents (TORDIA) study and to jointly model tolerability and efficacy for the specific SSRI comparisons. Methods: Efficacy and tolerability data for paroxetine, citalopram, and fluoxetine were extracted from the TORDIA study. Using a joint bivariate normal likelihood for response and tolerability (based on the maximum implied variance from the 95% credible intervals previously reported for the three SSRIs), a Monte Carlo pseudorandom sample (100,000 draws) was obtained, from which credible intervals, means, posterior tail probabilities, etc. were determined. Joint null hypotheses of no difference in efficacy and tolerability were then evaluated with regard to superiority of each SSRI over the others. Results: No significant differences in response were observed for citalopram compared with fluoxetine (p = 0.247) or for fluoxetine compared with paroxetine (p = 0.110), although citalopram trended toward being superior to paroxetine (mean difference: 0.2, ...Continue Reading

References

Jan 1, 1976·Neuropsychologia·A L Thompson, J F Marsh
Jul 5, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·M B KellerJ P McCafferty
Oct 5, 2002·Journal of the American Academy of Child and Adolescent Psychiatry·Graham J EmslieJennie G Jacobson
Aug 19, 2004·JAMA : the Journal of the American Medical Association·John MarchUNKNOWN Treatment for Adolescents With Depression Study (TADS) Team
Dec 2, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert L FindlingTheodore M Danoff
Mar 8, 2006·Archives of General Psychiatry·Tarek A HammadJudith Racoosin
Mar 24, 2006·Journal of Child and Adolescent Psychopharmacology·Robert L FindlingEric A Youngstrom
May 25, 2006·Journal of the American Academy of Child and Adolescent Psychiatry·Graham J EmslieChristel Wilkinson
Oct 3, 2007·Archives of General Psychiatry·John S MarchJoanne Severe
May 26, 2009·Journal of the American Academy of Child and Adolescent Psychiatry·Graham J EmslieStavros Tourkodimitris
Sep 3, 2009·The American Journal of Psychiatry·UNKNOWN Treatment for Adolescents With Depression Study (TADS) TeamMarla Bartoi
Nov 1, 2008·Cognitive and Behavioral Practice·Beth D KennardGraham J Emslie
Nov 3, 2010·Archives of General Psychiatry·John CurryJohn March
Jul 22, 2011·The Annals of Pharmacotherapy·Cynthia A FontanellaJohn V Campo
May 1, 2012·Journal of Clinical Psychopharmacology·David CohenClaudine Laurent
Aug 15, 2013·Annals of General Psychiatry·Konstantinos N FountoulakisHans-Jürgen Möller
Apr 7, 2017·Journal of Child and Adolescent Psychopharmacology·Jeffrey R StrawnMoira A Rynn
Aug 29, 2017·Journal of Child and Adolescent Psychopharmacology·Jeffrey R StrawnPaul E Croarkin
Feb 13, 2019·The Journal of Clinical Psychiatry·Eric T DobsonJeffrey R Strawn

❮ Previous
Next ❯

Citations

May 9, 2019·Journal of Child and Adolescent Psychopharmacology·Ethan A PoweleitLaura B Ramsey
Apr 22, 2020·Journal of Child and Adolescent Psychopharmacology·Jeffrey R StrawnPaul E Croarkin
Nov 5, 2019·Journal of the American Academy of Child and Adolescent Psychiatry·Jeffrey A Mills, Jeffrey R Strawn
Dec 17, 2021·Clinical and Translational Science·Stephani L StancilJeffrey R Strawn

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

DeclareMathSizes
Julia

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
H NordengO Spigset
© 2022 Meta ULC. All rights reserved