Switching to duloxetine in selective serotonin reuptake inhibitor non- and partial-responders: effects on painful physical symptoms of depression

Journal of Psychiatric Research
David PerahiaAlan F Schatzberg

Abstract

Painful physical symptoms (PPS) are common in patients with depression. Our objective was to evaluate the presence of PPS in a sample of SSRI non- or partial-responders with MDD and examine the effect of a switch to duloxetine on those PPS. Outpatients who met criteria for MDD despite having taken an SSRI antidepressant for at least 6 weeks, and who had a Hamilton depression rating scale total score of at least 15 and a clinical global impression of severity score of at least 3, were randomized to switch to duloxetine by either a direct switch or a start-taper switch method. PPS were assessed at baseline and at the study endpoint using various measures including six visual analog scales (VAS) for pain (overall pain, headache, back pain, shoulder pain, interference with daily activities, and time in pain while awake), the pain subscale of the symptom questionnaire-somatic subscale, and the bodily pain subscale of the short form-36 item health survey. Clinically significant levels of pain (mean baseline VAS scores >30 mm) were seen across all VAS pain measures prior to switching. Switch to duloxetine was associated with significant improvements on all pain measures regardless of switch method, and there was evidence for an earlie...Continue Reading

References

Jan 1, 1991·Annual Review of Neuroscience·H L FieldsP Mason
Mar 7, 2002·Archives of General Psychiatry·Michael E ThaseWilma Harrison
May 22, 2002·The Journal of Clinical Psychiatry·Stephen M Stahl
Dec 14, 2002·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael BauerUNKNOWN World Federation of Societies Biological Psychiatry Task Force on Treatment Guidelines for Unipolar Depressive Disorders
Jan 7, 2003·Archives of General Psychiatry·Maurice M Ohayon, Alan F Schatzberg
Nov 12, 2003·Archives of Internal Medicine·Matthew J BairKurt Kroenke
Jul 10, 2004·Journal of General Internal Medicine·Teri GrecoKurt Kroenke
Oct 27, 2004·Journal of Psychiatric Research·Stephen K BrannanAlan F Schatzberg
Dec 14, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Michael J DetkeIstvan Bitter
Mar 7, 2006·Journal of Affective Disorders·Koen DemyttenaereJordi Alonso
Mar 24, 2006·The New England Journal of Medicine·A John RushUNKNOWN STAR*D Study Team
Oct 3, 2006·International Clinical Psychopharmacology·David G S PerahiaJoel Raskin
Oct 17, 2007·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Thomas N WiseVicenzio Holder-Perkins

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Citations

Nov 17, 2010·International Journal of Clinical Practice·D SagmanJ Raskin
Feb 12, 2011·Arthritis Care & Research·Philip J MeaseAmy S Chappell
Jul 19, 2015·Psychiatry Research·Melissa Furtado, Martin A Katzman
Dec 27, 2011·Pharmaceutical Biology·Qing-Qiu MaoChun-Tao Che
Dec 18, 2019·The Cochrane Database of Systematic Reviews·Philippa DaviesNicola Wiles
Nov 5, 2016·Journal of Clinical Psychopharmacology·Martin A KatzmanLeena Anand

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