Switching to tenofovir vs continuing entecavir for hepatitis B virus with partial virologic response to entecavir: a randomized controlled trial

Journal of Viral Hepatitis
Hyung Joon YimK S Byun

Abstract

Entecavir 0.5 mg (ETV) is widely used among treatment-naïve chronic hepatitis B (CHB) patients. However, 10%-30% of patients show partial virologic response (PVR) to the drug. If the hepatitis B virus (HBV) continues to replicate, the underlying liver disease may progress. Herein, we compared the efficacy of switching to tenofovir disoproxil fumarate (TDF) with that of continuing ETV in CHB patients with PVR to ETV. This was an open-label randomized controlled trial including CHB patients who had been receiving 0.5 mg of ETV for >12 months, but who still had detectable HBV DNA levels of >60 IU/mL without known resistance to ETV. Sixty patients were enrolled and 45 qualified for the study: Twenty-two patients were randomly assigned into the TDF group and 23 into the ETV group. After 12 months of treatment, the virologic response rate (HBV DNA <20 IU/mL) was significantly higher in the TDF group than in the ETV group, as measured using per-protocol analysis (55% vs 20%; P = .022) and intention-to-treat analysis (50% vs 17.4%; P = .020). The reduction in HBV DNA was greater (-1.13 vs -0.67 log10 IU/mL; P = .024), and the mean HBV DNA level was lower (1.54 vs 2.01 log10 IU/mL; P = .011) in the TDF group than in the ETV group. In co...Continue Reading

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Citations

Apr 19, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Eiichi OgawaUNKNOWN Kyushu University Liver Disease Study (KULDS) Group
Jun 24, 2020·Clinical and Molecular Hepatology·Jung Hee Kim, Dong Hyun Sinn
Jun 13, 2019·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver (KASL)
Apr 25, 2019·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Ji Hoon Kim
Jul 29, 2021·World Journal of Gastrointestinal Pharmacology and Therapeutics·Niraj James ShahKumar Pallav
Aug 14, 2021·Revista de gastroenterología de México·F Higuera-de-la-TijeraE Wolpert-Barraza

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