Syk/Src pathway-targeted inhibition of skin inflammatory responses by carnosic acid.

Mediators of Inflammation
Jueun OhJae Youl Cho

Abstract

Carnosic acid (CA) is a diterpene compound exhibiting antioxidative, anticancer, anti-angiogenic, anti-inflammatory, anti-metabolic disorder, and hepatoprotective and neuroprotective activities. In this study, the effect of CA on various skin inflammatory responses and its inhibitory mechanism were examined. CA strongly suppressed the production of IL-6, IL-8, and MCP-1 from keratinocyte HaCaT cells stimulated with sodium lauryl sulfate (SLS) and retinoic acid (RA). In addition, CA blocked the release of nitric oxide (NO), tumor necrosis factor (TNF)-α, and prostaglandin E₂ (PGE₂) from RAW264.7 cells activated by the toll-like receptor (TLR)-2 ligands, Gram-positive bacterium-derived peptidoglycan (PGN) and pam3CSK, and the TLR4 ligand, Gram-negative bacterium-derived lipopolysaccharide (LPS). CA arrested the growth of dermatitis-inducing Gram-positive and Gram-negative microorganisms such Propionibacterium acnes, Pseudomonas aeruginosa, and Staphylococcus aureus. CA also blocked the nuclear translocation of nuclear factor (NF)-κB and its upstream signaling including Syk/Src, phosphoinositide 3-kinase (PI3K), Akt, inhibitor of κBα (IκBα) kinase (IKK), and IκBα for NF-κB activation. Kinase assays revealed that Syk could be direc...Continue Reading

References

Feb 1, 1992·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·O I AruomaJ Löligers
Aug 1, 1988·Journal of Virological Methods·R PauwelsE De Clercq
Jan 1, 1986·Reviews of Infectious Diseases·M E Kingston, D Mackey
Jan 1, 1997·Arthritis and Rheumatism·G R BurmesterR W Kinne
Nov 24, 1999·The Journal of Clinical Investigation·J A GracieI B McInnes
Nov 30, 2000·Arthritis Research·R W KinneG R Burmester
Sep 14, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·K Takeda, S Akira
Feb 6, 2004·Journal of the European Academy of Dermatology and Venereology : JEADV·S Briganti, M Picardo
Feb 8, 2005·The Journal of Allergy and Clinical Immunology·Anja P BienemanJohn T Schroeder
Apr 27, 2005·Brain Research. Brain Research Reviews·Trevor OwensHenrik Toft-Hansen
Jun 1, 2005·Journal of Cutaneous Medicine and Surgery·Sari M Herman, Ronald B Vender
Oct 6, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Jenny Kim
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuichi SekineTadashi Matsuda
Nov 28, 2007·Experimental Biology and Medicine·Beong Ou LimWahn Soo Choi
Mar 6, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M R SohailA Virk
Jun 25, 2009·Current Opinion in Allergy and Clinical Immunology·Peter M Elias, Matthias Schmuth
Jun 27, 2009·Experimental Dermatology·Ichiro KurokawaChristos C Zouboulis
Jun 30, 2009·International Journal of Antimicrobial Agents·Matthew S Dryden
Sep 3, 2009·Journal of Food Protection·Anja KlancnikSonja Smole Mozina
Sep 23, 2009·Biochemical Pharmacology·Joo Young KimJae Youl Cho
Mar 2, 2010·Archives of Pharmacal Research·Young-Soo KimDeokhoon Park
Apr 7, 2010·Archives of Biochemistry and Biophysics·Albena T Dinkova-Kostova, Paul Talalay
Sep 8, 2010·Chemico-biological Interactions·Thérèse SergentYves-Jacques Schneider
Mar 31, 2011·Food Science and Technology International = Ciencia Y Tecnología De Los Alimentos Internacional·F Pop
Jun 17, 2011·The Journal of Investigative Dermatology·Jordan S FridmanKris Vaddi
Sep 1, 2011·Acta Dermato-venereologica·Ilkka T Harvima, Gunnar Nilsson
Dec 21, 2011·Journal of Ethnopharmacology·Yanyan YangJae Youl Cho
Jan 5, 2012·Biochemical and Biophysical Research Communications·Mika YanagitaiTakumi Satoh
Jan 11, 2012·Bioscience, Biotechnology, and Biochemistry·Tomoko Kayashima, Kiminori Matsubara

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Citations

Mar 22, 2013·Journal of Medicinal Food·Tsung-Hsien TsaiPo-Jung Tsai
Feb 8, 2014·Journal of Ethnopharmacology·Deok JeongJae Youl Cho
Nov 23, 2013·Free Radical Biology & Medicine·Takumi SatohStuart A Lipton
Aug 20, 2015·Critical Reviews in Food Science and Nutrition·Ji Hye JeongDae Kyun Chung
Jan 9, 2013·Journal of Ethnopharmacology·Deok JeongJae Youl Cho
Feb 3, 2015·Phytochemistry·Simona BirtićMarc Roller
Aug 14, 2012·Journal of Ethnopharmacology·Hye Yoon JeongJae Youl Cho
Jul 31, 2013·Free Radical Biology & Medicine·Takumi SatohStuart A Lipton
Dec 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Qisen XiangXuebo Liu
Oct 4, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sana BahriVadim Shlyonsky
Oct 18, 2014·Nutrition Research and Practice·Mi-Young Park, Seong Taek Mun
Feb 3, 2015·Natural Product Reports·Miguel A González
Jan 10, 2020·Current Pharmaceutical Biotechnology·Huey-Chun HuangTsong-Min Chang
Jul 5, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Dinesh ThummuriPradip Chaudhari
Jul 7, 2017·Mediators of Inflammation·Jae Gwang ParkJae Youl Cho
Oct 16, 2019·Experimental and Therapeutic Medicine·Quan LiKunyue Cao

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
Assay
transfection
Immunoprecipitation
profiler
nuclear translocation

Software Mentioned

SPSS

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