Symmetric and asymmetric mitotic segregation patterns influence Wolbachia distribution in host somatic tissue.

Journal of Cell Science
Roger AlbertsonWilliam Sullivan

Abstract

Wolbachia are maternally inherited bacterial endosymbionts that occupy many but not all tissues of adult insects. During the initial mitotic divisions in Drosophila embryogenesis, Wolbachia exhibit a symmetric pattern of segregation. Wolbachia undergo microtubule-dependent and cell-cycle-regulated movement between centrosomes. Symmetric segregation occurs during late anaphase when Wolbachia cluster around duplicated and separating centrosomes. This centrosome association is microtubule-dependent and promotes an even Wolbachia distribution throughout the host embryo. By contrast, during the later embryonic and larval neuroblast divisions, Wolbachia segregate asymmetrically with the apical self-renewing neuroblast. During these polarized asymmetric neuroblast divisions, Wolbachia colocalize with the apical centrosome and apically localized Par complex. This localization depends on microtubules, but not the cortical actin-based cytoskeleton. We also found that Wolbachia concentrate in specific regions of the adult brain, which might be a direct consequence of the asymmetric Wolbachia segregation in the earlier neuroblast divisions. Finally, we demonstrate that the fidelity of asymmetric segregation to the self-renewing neuroblast ...Continue Reading

References

Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·J A KnoblichY N Jan
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·K T Min, S Benzer
Apr 2, 1998·European Journal of Cell Biology·M G Riparbelli, G Callaini
Apr 10, 1999·Insect Biochemistry and Molecular Biology·S L DobsonS L O'Neill
Oct 8, 1999·Parasitology Today·M J Taylor, A Hoerauf
Sep 12, 2001·Methods in Cell Biology·U TramW Sullivan
Nov 9, 2001·Annual Review of Genetics·U TepassR Fehon
Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·E A McGrawS L O'Neill
Jan 25, 2003·Nature Cell Biology·Roger Albertson, Chris Q Doe
Mar 20, 2003·Trends in Parasitology·Stephen L Dobson
Nov 19, 2003·Mechanisms of Development·Andreas Wodarz, Wieland B Huttner
Aug 4, 2004·Molecular and Biochemical Parasitology·Helen F McGarryMark J Taylor
Sep 4, 2004·Applied and Environmental Microbiology·Zoe VenetiKostas Bourtzis
Dec 22, 2004·Current Topics in Microbiology and Immunology·S B Sieczkarski, G R Whittaker
Mar 19, 2005·Genome Biology·Steven L SalzbergWilliam C Nelson
Aug 16, 2005·Current Opinion in Cell Biology·Andreas Wodarz
Jan 7, 2006·Development·Sarah E Siegrist, Chris Q Doe
Mar 10, 2006·Journal of Cell Science·Atsushi Suzuki, Shigeo Ohno
Mar 30, 2006·Evolution; International Journal of Organic Evolution·Katerina KoukouStamatis N Alahiotis
May 26, 2006·Nature·Horacio M FrydmanEric Wieschaus
Jun 17, 2006·Proceedings. Biological Sciences·Fleur E Champion de Crespigny, Nina Wedell

❮ Previous
Next ❯

Citations

Jun 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Michelle E ToomeyHoracio M Frydman
May 31, 2011·Applied and Environmental Microbiology·Catharina Casper-LindleyWilliam Sullivan
Dec 24, 2011·Journal of Cell Science·Laura R SerbusWilliam Sullivan
Jul 17, 2014·ELife·Jeremy K HerrenBruno Lemaitre
Dec 18, 2015·Frontiers in Zoology·Noémie Templé, Freddie-Jeanne Richard
Mar 16, 2013·Cellular Microbiology·Roger AlbertsonCatharina Casper-Lindley
Dec 18, 2012·The Biochemical Journal·Yoan Diekmann, José B Pereira-Leal
Apr 24, 2015·PLoS Pathogens·Irene L G NewtonKathy B Sheehan
Jun 30, 2016·Cellular Microbiology·Anton StrunovWolfgang J Miller
Jul 28, 2016·MicrobiologyOpen·Jose E PietriWilliam Sullivan
Sep 22, 2016·Nature Communications·Toshiyuki HarumotoTakema Fukatsu
Oct 22, 2019·Insect Science·Jie Bi, Yu-Feng Wang
Mar 23, 2018·Proceedings. Biological Sciences·Toshiyuki HarumotoBruno Lemaitre
Nov 21, 2018·Behavior Genetics·Daniela I SchneiderWolfgang J Miller
Oct 8, 2020·MBio·Michael T J HagueBrandon S Cooper
May 6, 2021·Biology Letters·Michael T J HagueBrandon S Cooper
Apr 7, 2019·Microbiology Spectrum·Frédéric Landmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.