Symmetric dimethylarginine (SDMA) outperforms asymmetric dimethylarginine (ADMA) and other methylarginines as predictor of renal and cardiovascular outcome in non-dialysis chronic kidney disease

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Insa E EmrichStefanie M Bode-Böger

Abstract

Chronic kidney disease (CKD) is associated with increased risk of renal and cardiovascular events. It has been claimed that endogenous methylarginines, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), are contributing factors. However, earlier studies were partly contradictory and mainly focused on prevalent dialysis patients. Moreover, the potential contribution of degradation products, such as acetylated ADMA and SDMA (AcADMA and AcSDMA) and other methylarginines including L-NG-monomethylarginine (LNMMA) remains unknown. To better understand their potential pathophysiological contribution to renal and cardiovascular events, we aimed to provide a comprehensive analysis of methylarginines in a cohort of patients with non-dialysis CKD. Blood samples of 528 patients with CKD KDIGO G2 to G4 were obtained from the CARE FOR HOMe study. Baseline plasma levels of ADMA, SDMA, AcADMA, AcSDMA, and LNMMA were measured by liquid chromatography-tandem mass spectrometry. All patients were followed annually for CKD progression and for incident atherosclerotic cardiovascular events. During 5.1 ± 2.1 years follow-up, 80 patients displayed CKD progression and 145 patients developed incident atherosclerotic cardiovascular...Continue Reading

References

Mar 1, 1997·Journal of the American College of Cardiology·A WolfJ P Cooke
Feb 1, 1997·Nitric Oxide : Biology and Chemistry·E I ClossU Förstermann
Dec 29, 2000·Journal of the American College of Cardiology·R H BögerJ P Cooke
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Jun 3, 2005·Journal of the American Society of Nephrology : JASN·Danilo FliserEberhard Ritz
Aug 23, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jan T Kielstein, Carmine Zoccali
Dec 27, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mahmut Ilker YilmazCarmine Zoccali
Feb 17, 2006·Journal of the American Society of Nephrology : JASN·Stefanie M Bode-BögerHolger Reinecke
Jun 13, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jan T KielsteinDanilo Fliser
Jun 23, 2006·Journal of the American Society of Nephrology : JASN·Stein I HallanJostein Holmen
Jan 10, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ko HanaiYasuhiko Iwamoto
Apr 25, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Jill Melendez YoungVandana Menon
Mar 30, 2011·Nature Reviews. Nephrology·Edzard Schwedhelm, Rainer H Böger
Jun 7, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Tse-Min LuShing-Jong Lin
Jun 7, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Giovanni TripepiCarmine Zoccali
Oct 2, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Ben CaplinJames Leiper
Oct 18, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Bob SiegerinkLutz P Breitling
Feb 25, 2014·Analytical Biochemistry·Jens Martens-LobenhofferStefanie M Bode-Böger
May 2, 2014·Seminars in Nephrology·Eva SchepersJan T Kielstein
Jun 28, 2014·Clinical Journal of the American Society of Nephrology : CJASN·David A DrewMark J Sarnak
Dec 2, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jens Martens-Lobenhoffer, Stefanie M Bode-Böger
Feb 11, 2015·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Thomas MeyerFrank Edelmann
Mar 11, 2015·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Wesley T O'NealElsayed Z Soliman
May 30, 2015·Journal of the American Heart Association·Peter WilleitRajiv Chowdhury
Jun 17, 2015·Amino Acids·Anne-Roos S FrenayHarry van Goor
Oct 31, 2015·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Tobias ZeusAmin Polzin
Nov 28, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Roman N RodionovStefanie M Bode-Böger
Jan 25, 2016·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Florian CustodisStefan Möhlenkamp
Sep 16, 2016·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Seung-Yul LeeGregg W Stone
Jan 17, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tariq ShafiNeil R Powe
Feb 9, 2017·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Peter Nørkjær LaursenJ Lønborg

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Citations

Feb 24, 2018·Journal of the American Society of Nephrology : JASN·Florian Kronenberg
Sep 13, 2019·Journal of Veterinary Internal Medicine·André Nanny Vieira Le SueurPriscylla Tatiana Chalfun Guimarães-Okamoto
Jul 6, 2020·Journal of Cosmetic Dermatology·Fatma Tuncez AkyurekArzu Ataseven
Jul 31, 2019·International Journal of Molecular Sciences·Elena Oliva-DamasoJose Carlos Rodriguez-Perez
Jun 27, 2019·Herz·I E EmrichM Böhm
Jul 29, 2020·Journal of Clinical Medicine·Stefanos RoumeliotisCarmine Zoccali
Aug 17, 2018·Scientific Reports·Thea HelmAnne-Lise Bjørke-Monsen
Mar 11, 2020·International Journal of Molecular Sciences·Gerrit M GrosseChi-Un Choe
Oct 4, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mario CozzolinoAndrea Galassi
Dec 24, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Kathrin WeidnerIbrahim Akin
Jan 11, 2020·Metabolism: Clinical and Experimental·Anouar HafianeMiguel A Frias
Dec 31, 2020·International Journal of Molecular Sciences·Irina LousaAlice Santos-Silva
Nov 11, 2021·Chembiochem : a European Journal of Chemical Biology·Zoey WarmerdamFraser Hof

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