Symmetrical infantile thalamic degeneration with focal cytoplasmic calcification.

Acta Neuropathologica
M Ambler, W O'Neil

Abstract

Infantile thalamic degeneration is a rare clinico-pathological entity. Restricted location of the lesion and peculiar cytopathological changes serve to distinguish this disorder from other common encephalopathies. Optical and ultrastructural studies demonstrate cytoplasmic calcopherules in previously viable cells. According to current concepts of acute cellular reactions to injury and mechanism of intracellular calcification, the cytological changes cannot be attributed to either hypoxic ischemic cell change or dystrophic calcification. By analogy to other human and pathological material, the most likely basis for nondystrophic calcopherule formation is toxic or infectious injury with local synthesis, or autophagic or phagolysosomal degradation of cellular debris of specific chemical composition favoring calcium deposition.

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Citations

Jan 1, 1983·Annals of Neurology·J E ParisiC J Crosley
Aug 15, 1994·American Journal of Medical Genetics·M S van der Knaap, P G Barth
Jan 1, 1984·Acta Neuropathologica·F G JennekensJ Westdorp
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Oct 6, 2000·Pediatric Neurology·S ChamnanvanakijJ M Perlman

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