Symmetry Breaking and Epithelial Cell Extrusion.

Cells
Bageshri Naimish NanavatiJessica L Teo

Abstract

Cell extrusion is a striking morphological event found in epithelia and endothelia. It is distinguished by two symmetry-breaking events: a loss of planar symmetry, as cells are extruded in either apical or basal directions; and loss of mechanochemical homogeneity within monolayers, as cells that are fated to be extruded become biochemically and mechanically distinct from their neighbors. Cell extrusion is elicited by many diverse events, from apoptosis to the expression of transforming oncogenes. Does the morphological outcome of extrusion reflect cellular processes that are common to these diverse biological phenomena? To address this question, in this review we compare the progress that has been made in understanding how extrusion is elicited by epithelial apoptosis and cell transformation.

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Citations

Apr 11, 2021·Cytoskeleton·Maria Teresa ParreiraKris Noel Dahl
Jun 8, 2021·Seminars in Cell & Developmental Biology·Giulia Paci, Yanlan Mao
Oct 11, 2021·Journal of Molecular Biology·Madeline J ChurchillIsabella Rauch

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Methods Mentioned

BETA
nucleotide exchange
GTPases
atomic force microscopy

Related Concepts

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis