DOI: 10.1101/491092Dec 8, 2018Paper

Symmetry breaking in the embryonic skin triggers a directional and sequential front of competence during plumage patterning

BioRxiv : the Preprint Server for Biology
Richard BailleulMarie Manceau

Abstract

The development of an organism involves the formation of patterns from initially homogeneous surfaces in a reproducible manner. Simulations of various theoretical models recapitulate final states of natural patterns1-4 yet drawing testable hypotheses from those often remains difficult4,5. Consequently, little is known on pattern-forming events. Here, we extend modeling to reproduce not only the final plumage pattern of birds, but also the observed natural variation in its dynamics of emergence in five species. We built a unified model intrinsically generating the directionality, sequence, and duration of patterning, and used in vivo experiments to test its parameter-based predictions. We showed that while patterning duration is controlled by overall cell proliferation, its directional and sequential progression result from a pre-pattern: an initial break in surface symmetry launches a traveling front of increased cell density that defines domains with self-organizing capacity. These results show that universal mechanisms combining pre-patterning and self-organization govern the timely emergence of the plumage pattern in birds.

Related Concepts

Aves
Theoretical Model
Surface
Direction
Patterns
Cell Proliferation
Simulation
Research Study
ETV4 gene
In Vivo

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

Nature Reviews. Molecular Cell Biology
Sebastian WennekampTakashi Hiiragi
Mathematical Biosciences and Engineering : MBE
Manuela CaratozzoloGiovanni Marletta
The Journal of Genetic Psychology
A GESELL, L B AMES
© 2021 Meta ULC. All rights reserved