Sympathectomy alters acetylcholinesterase expression in adult rat heart

Cardiovascular Research
C Nyquist Battie, N Moran

Abstract

The aim of the study was to determine the significance of adrenergic nerve associated acetylcholinesterase for the pool of total acetylcholinesterase molecules. Acetylcholinesterase was analysed after destruction of adrenergic nerves by 6-hydroxydopamine or bilateral stellate sympathectomy. Effectiveness of treatment was verified by determining noradrenaline concentrations in right ventricle. Acetylcholinesterase activity was assayed in homogenates of atria and portions of left ventricular free wall. Adult male Sprague-Dawley rats were used, weight 225-260 g, n = 5 per experimental group. Sympathectomy caused a small decrease in acetylcholinesterase activity, due to a decrease in the activity of the tetrameric globular form of the enzyme. Choline acetylcholinesterase activity was not altered by sympathectomy, which is an indication that cholinergic nerves were not affected. The contribution of adrenergic neurones to the cardiac pool of acetylcholinesterase is measurable and consists primarily of the tetrameric globular form of the enzyme.

Citations

Jan 1, 1996·British Journal of Pharmacology·C L Beauregard, P G Smith
Aug 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R Camarini, M A Benedito
Jan 21, 1992·International Journal of Cancer. Journal International Du Cancer·M TatsutaH Taniguchi

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