Sympathetic activation in exercise is not dependent on muscle acidosis. Direct evidence from studies in metabolic myopathies

The Journal of Clinical Investigation
J VissingR G Haller

Abstract

Muscle acidosis has been implicated as a major determinant of reflex sympathetic activation during exercise. To test this hypothesis we studied sympathetic exercise responses in metabolic myopathies in which muscle acidosis is impaired or augmented during exercise. As an index of reflex sympathetic activation to muscle, microneurographic measurements of muscle sympathetic nerve activity (MSNA) were obtained from the peroneal nerve. MSNA was measured during static handgrip exercise at 30% of maximal voluntary contraction force to exhaustion in patients in whom exercise-induced muscle acidosis is absent (seven myophosphorylase deficient patients; MD [McArdle's disease], and one patient with muscle phosphofructokinase deficiency [PFKD]), augmented (one patient with mitochondrial myopathy [MM]), or normal (five healthy controls). Muscle pH was monitored by 31P-magnetic resonance spectroscopy during handgrip exercise in the five control subjects, four MD patients, and the MM and PFKD patients. With handgrip to exhaustion, the increase in MSNA over baseline (bursts per minute [bpm] and total activity [%]) was not impaired in patients with MD (17+/-2 bpm, 124+/-42%) or PFKD (65 bpm, 307%), and was not enhanced in the MM patient (24 bp...Continue Reading

References

Jun 1, 1992·The Journal of Clinical Investigation·L I SinowayA L Mark
Oct 1, 1988·The Journal of Clinical Investigation·R G VictorR L Nunnally
Sep 1, 1987·Pflügers Archiv : European journal of physiology·F Thimm, K Baum
Mar 1, 1985·Respiration Physiology·F L EldridgeT G Waldrop
Sep 1, 1984·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D L ArnoldG K Radda
Mar 1, 1984·Pflügers Archiv : European journal of physiology·F ThimmE Meier zu Verl
Oct 1, 1996·Annals of Neurology·J VissingR G Haller

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Citations

Aug 5, 2010·European Journal of Applied Physiology·Dale E RaeAlejandro Lucia
Oct 17, 2002·Respiratory Physiology & Neurobiology·Jerome A DempseyBarbara J Morgan
Jan 22, 2000·Molecular Aspects of Medicine·C Boesch
Jun 28, 2000·Journal of the Autonomic Nervous System·S E O'Sullivan, C Bell
May 21, 2010·Seminars in Musculoskeletal Radiology·Gregory ChangRavinder R Regatte
Dec 26, 2003·The New England Journal of Medicine·John Vissing, Ronald G Haller
Mar 18, 2003·The Journal of Physiology·Marc P Kaufman
Aug 16, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Megan N MurphyScott A Smith
Aug 30, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Shawn G HayesMarc P Kaufman
Jul 17, 2014·Sports Medicine·Alfredo SantallaAlejandro Lucia
Dec 2, 2000·The Journal of Physiology·C M St CroixJ A Dempsey
Mar 31, 2007·The Journal of Physiology·Shawn G HayesMarc P Kaufman
May 23, 2013·Muscle & Nerve·Yaacov Anziska, Alex Sternberg
Aug 15, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Tadaaki ManoShinobu Toma
Jun 8, 2013·International Journal of Cardiology·Matthew G D BatesGráinne S Gorman
Jun 8, 2017·Annals of the American Thoracic Society·Marshall S RileyChristopher B Cooper
Dec 14, 2011·The Cochrane Database of Systematic Reviews·Rosaline QuinlivanJohn Buckley
Nov 13, 2014·The Cochrane Database of Systematic Reviews·Rosaline QuinlivanBenedikt Schoser
Jan 30, 2007·Journal of Magnetic Resonance Imaging : JMRI·Chris Boesch
Jul 23, 2005·Journal of Applied Physiology·Lawrence I Sinoway, Jianhua Li
Jul 22, 2008·Journal of Applied Physiology·E S Prakash
Dec 16, 1998·Current Opinion in Neurology·S DiMauro, C Bruno
Mar 16, 2002·Journal of Applied Physiology·P Alexander DerchakJerome A Dempsey
Mar 31, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Keisho KatayamaMitsuru Saito
Jun 6, 2020·Journal of Clinical Medicine·Hugo Fernandez-RubioJ L Chicharro
Oct 7, 1998·Journal of Applied Physiology·D A MacLeanL I Sinoway
Mar 11, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D A MacLeanL I Sinoway
May 23, 2006·Journal of Applied Physiology·Michael Ivan Lindinger
Aug 18, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dieter BöningNorbert Maassen
Jun 9, 2020·Frontiers in Physiology·Tina Dysgaard Jeppesen
Aug 13, 1999·Journal of Applied Physiology·C J PritzlaffA Weltman
Feb 14, 2021·International Journal of Environmental Research and Public Health·Hugo Fernández-RubioJose López Chicharro
Jun 13, 2006·Journal of Applied Physiology·Russell Tupling
Aug 6, 2008·Journal of Applied Physiology·Ralph Beneke

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