Sep 4, 1998

Sympathetic activity in obese subjects with and without obstructive sleep apnea

Circulation
K NarkiewiczV K Somers

Abstract

Obese humans are reported to have increased muscle sympathetic nerve activity (MSNA). Obstructive sleep apnea (OSA) may also be accompanied by increased MSNA. Because there is a high prevalence of OSA in obese humans, it is possible that high MSNA reported in obese subjects may in fact reflect the presence of OSA in these subjects. We tested the hypothesis that obesity, per se, in the absence of OSA, is not accompanied by increased MSNA. We measured MSNA in 25 healthy normal-weight subjects and 30 healthy sedentary obese subjects. All subjects were screened by history and examination to exclude subjects with OSA or hypertension. OSA was further excluded by overnight polysomnographic studies. Despite careful screening, polysomnography revealed that 1 of 25 normal-weight subjects and 9 of 30 obese subjects had occult OSA (P=0.015). MSNA was similar in normal-weight subjects (41+/-3 bursts per 100 heartbeats) and obese subjects without sleep apnea (42+/-3 bursts per 100 heartbeats, P=0.99). MSNA in the 9 obese subjects with occult OSA was 61+/-8 bursts per 100 heartbeats, which was higher than MSNA in normal-weight subjects without sleep apnea (P=0.02) and higher than MSNA in obese subjects without sleep apnea (P=0.02). Obesity al...Continue Reading

  • References22
  • Citations226

References

Mentioned in this Paper

Heart Beat
Hypersomnia With Periodic Respiration
Sympathetic Nervous System
Log-Linear Models
Blood Vessel
Sympathetic Nerve Structure
Entire Sympathetic Nerve
Soleus Muscle Structure
Obesity
Hypertensive Disease

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