Sympathetic alternans. Evidence for arterial baroreflex control of muscle sympathetic nerve activity in congestive heart failure

Circulation
S AndoJohn S Floras

Abstract

Alternation in the amplitude of muscle sympathetic nerve activity (MSNA) was documented in three patients with severe heart failure. In the index patient with pulsus alternans, the amplitude of MSNA was inversely related to changes in the preceding diastolic pressure with a lag time of 1.2 to 1.3 seconds, indicating that oscillations in burst amplitude are determined primarily by changes in this component of blood pressure. Spectral analysis of the blood pressure and MSNA signals identified two spectral peaks, one at the cardiac frequency and a second peak, with greater spectral power, at the alternans frequency (ie, at half the heart rate). The latter peak for both blood pressure and MSNA disappeared when alternans was abolished by nitroglycerin. The presence of sympathetic alternans in synchrony with pulsus alternans and the rapid transduction of changes in the diastolic blood pressure afferent signal to the amplitude of sympathetic outflow indicate that the arterial baroreflex control of MSNA must be active and rapidly responsive in human heart failure.

References

Jan 1, 1978·The Journal of Physiology·G Sundlöf, B G Wallin
Aug 1, 1992·Journal of the American College of Cardiology·B Surawicz, C Fisch
Feb 15, 1992·The American Journal of Cardiology·D W FergusonA L Mark
Feb 1, 1989·Journal of Applied Physiology·J S Sanders, D W Ferguson
Oct 14, 1971·The New England Journal of Medicine·D L EckbergE Braunwald
Sep 1, 1980·Journal of the Neurological Sciences·J Fagius, B G Wallin
May 1, 1995·Progress in Cardiovascular Diseases·I H ZuckerK P Patel
Feb 1, 1994·Journal of the American College of Cardiology·M A Creager, S J Creager
Jan 1, 1994·The American Journal of Physiology·G F DiBona, L L Sawin
Oct 1, 1993·Journal of the American College of Cardiology·J S Floras
Feb 1, 1996·Journal of the American College of Cardiology·M E Dibner-DunlapM D Thames

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Citations

Nov 13, 2008·Annals of Biomedical Engineering·Koji KashiharaKenji Sunagawa
Sep 2, 1998·Progress in Neurobiology·S C Malpas
Jan 12, 2000·Journal of Cardiovascular Pharmacology·E R AzevedoJ D Parker
Mar 21, 1998·The Journal of Clinical Investigation·G A RongenJ S Floras
Apr 27, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Toshihiko KuboJohn S Floras
Mar 24, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shigeto MorimotoMasayuki Matsumoto
Aug 2, 2002·Biomedizinische Technik. Biomedical Engineering·U LederA Voss
May 13, 2008·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yasuhiro MieFumio Mizutani
Mar 7, 2000·Journal of Hypertension·A RadaelliA U Ferrari
Mar 1, 2003·Acta Physiologica Scandinavica·Guido GrassiGiuseppe Mancia
Nov 9, 2002·The American Journal of Cardiology·Daniel RoachRobert Sheldon
Mar 11, 2015·Pacing and Clinical Electrophysiology : PACE·Mathias BaumertLarisa G Tereshchenko
Jun 19, 2007·Orvosi hetilap·Tamás Szili-TörökLászló Rudas
Jul 25, 2009·Journal of the American College of Cardiology·John S Floras
Dec 3, 2016·Journal of Cardiac Failure·John S Floras, Noe Zamel
Mar 24, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jian CuiLawrence I Sinoway
Sep 14, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paola A Lanfranchi, Virend K Somers
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A GabrielsenP Norsk
Feb 27, 2021·Clinical Science·Catherine F Notarius, John S Floras
Jul 15, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John S Floras

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