PMID: 6989757Jan 1, 1980Paper

Sympathetic and renin-angiotensin system influence on blood pressure and renal blood flow of two-kidney, one clip Goldblatt hypertensive dog

Hypertension
B G ZimmermanE Kraft

Abstract

Conscious normotensive and two-kidney, one clip Goldblatt hypertensive dogs were studied to determine the influence of the sympathetic and renin-angiotensin systems on the blood pressure and renal blood flow. Renal blood flow was monitored in a single kidney of the normotensive dogs and in the contralateral kidney of the hypertensive dogs. Saralasin was infused intravenously (i.v.) at 1 microgram/kg/min for 15 minutes in untreated and guanethidine-treated animals. Guanethidine (i.v.) decreased blood pressure (BP) in the hypertensives at X = 16 days after Goldblatt clamp application, but not in the normotensives, and did not affect renal blood flow or vascular resistance in either group. Saralasin produced approximately the same BP decrease in both untreated and guanethidine-treated hypertensives at X = 12 days after Goldblatt clamp application; the combined effect of the drugs was greater than saralasin alone. Blood flow and vascular resistance of the hypertensives' contralateral kidney were not significantly affected by saralasin in these experiments. No sustained effect on BP or renal blood flow was obtained with saralasin in the normotensives. Administration of furosemide was utilized to increase plasma renin activity (PRA) ...Continue Reading

References

Jun 5, 1976·Lancet·J J BrownP Trust
Oct 18, 1978·Pflügers Archiv : European journal of physiology·H G Glitsch, L Pott
Mar 1, 1976·Progress in Cardiovascular Diseases·M J Brody, B G Zimmerman
Feb 1, 1977·Clinical Science and Molecular Medicine·J L ImbsJ Schwartz
May 1, 1977·Clinical Science and Molecular Medicine·N C TrippodoA C Guyton
Feb 25, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·O AlmgrenA Carlsson
Sep 1, 1976·The American Journal of Physiology·B E WatkinsR H Freeman
Sep 1, 1975·The American Journal of Physiology·S Satoh, B G Zimmerman
Jan 1, 1975·Annals of Internal Medicine·L WallachK G Dawson
Dec 1, 1970·The American Journal of Physiology·M J BrodyR A Shaffer
Aug 1, 1971·British Journal of Pharmacology·R S Grewal, C L Kaul
Jul 1, 1971·Circulation Research·H W OverbeckM C Fleck
Sep 1, 1969·The American Journal of Physiology·B G ZimmermanJ L Gisslen
Oct 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·L D Dorr, M J Brody
Dec 1, 1961·The American Journal of Physiology·A C TAQUINID F BOHR

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Citations

Dec 29, 2000·American Journal of Veterinary Research·C BuranakarlK C Bovée
Feb 1, 1985·Pflügers Archiv : European journal of physiology·G J JonkerG K van der Hem
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·C J MathiasS Peart
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·T Nakada, Y Yamori
Feb 1, 1982·Kidney International·S G RostandL G Navar

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