PMID: 9430803Feb 7, 1998Paper

Sympathetic cardiovascular dysfunction in long-standing idiopathic Parkinson's disease

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
D LindenP Berlit

Abstract

Standard autonomic tests (heart rate response to deep breathing--HRDB, heart rate and systolic blood pressure response to tilt--delta HR and delta SBP) and spectral analysis of heart rate and arterial blood pressure and their transfer function (for the mid-frequency band a measure of baroreflex sensitivity) were performed in 20 patients with idiopathic Parkinson's disease (IPD) and 20 age-matched controls. Patients showed significantly diminished delta SBP, and reduced sympathetic vasomotor and cardiomotor outflow (diminished Mayer waves), consistent with an alteration of the efferent arc of the baroreflex. These results were only significant in long-standing IPD (IPD-l, > 5 years), whereas patients with short disease duration (IPD-s, < 5 years) showed values comparable to controls. Respiratory-related heart rate variability was slightly reduced in IPD-1 but this was mainly due to diminished respiratory effort, indicated by low respiratory-related blood pressure variability. We conclude that autonomic abnormalities are only present in long-standing IPD and consist in reduced sympathetic vasomotor and cardiomotor outflow.

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Citations

Feb 16, 2006·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·David S Goldstein
Apr 26, 2012·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Rachael BrownVaughan G Macefield
May 30, 2001·Neurobiology of Aging·T Szili-TörökL Rudas
Dec 16, 1998·Electroencephalography and Clinical Neurophysiology·D LindenP Berlit
Mar 25, 2014·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Mohan GanesanTalakad N Sathyaprabha
Jun 24, 2017·Frontiers in Neurology·Wei-Che LinCheng-Hsien Lu

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