Jan 1, 1976

Sympathetic cardiovascular effects of experimental strychnine poisoning in dogs

The Journal of Pharmacology and Experimental Therapeutics
O A Sofola, K A Odusote


The cardiovascular effects of intravenously administered strychnine were studied in anesthetized and paralyzed dogs. Administration of strychnine in cumulative doses of up to 0.1 to 0.2 mg/kg caused significant pressor, as well as positive inotropic and chronotropic, effects on the heart which were abolished by adrenergic blocking agents. The cardiovascular responses possibly were elicited by a central mechanism in contrast to the peripheral inhibitory action of strychnine on the sympathetic system. Diazepam caused a marked attenuation of the pressor response with only slight changes on the heart. A combination of diazepam and propranolol would appear to be a useful therapy in cases of strychnine poisoning showing marked cardiovascular excitation.

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Mentioned in this Paper

Sympathetic Nervous System
Strychnine Assay
Diastolic Blood Pressure
Poisoning Aspects
Adrenergic alpha-Antagonists
Strychnine Nitrate

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