Sympathetic cholinergic target innervation requires GDNF family receptor GFR alpha 2

Molecular and Cellular Neurosciences
Päivi H Hiltunen, M S Airaksinen

Abstract

Many cholinergic parasympathetic and enteric neurons require neurturin signaling through GDNF family receptor GFRalpha2 for target innervation. Since a distinct minority of sympathetic neurons are cholinergic, we examined whether GFRalpha2 is important for their development. We detected GFRalpha2 in neonatal sympathetic cholinergic neurons and neurturin mRNA in their target tissues, sweat glands in footpads, and periosteum. Lack of GFRalpha2 in mice did not affect the number of sympathetic cholinergic neurons, but their soma size was decreased in comparison to wild types. In adult and in 3-week-old GFRalpha2 knockout mice, the density of sympathetic cholinergic innervation was reduced by 50-70% in the sweat glands, and was completely absent in the periosteum. Sympathetic noradrenergic innervation of blood vessels in the footpads was unchanged. The density of sympathetic axons in sweat glands was unaffected at postnatal day P4 reflecting successful growth into the target area. Our results indicate that the cholinergic subpopulation of sympathetic neurons requires GFRalpha2 signaling for soma size and for growth or maintenance of target innervation. Thus, neurturin may be a general target-derived innervation factor for postgangli...Continue Reading

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Citations

Jul 19, 2005·Annual Review of Neuroscience·Natalia O Glebova, David D Ginty
Oct 12, 2005·The Journal of Comparative Neurology·Eberhard WeiheLee E Eiden
Aug 17, 2006·Brain, Behavior and Evolution·Matti S AiraksinenTuomas Hätinen
Oct 27, 2018·Blood·Andrés García-GarcíaSimón Méndez-Ferrer
Dec 22, 2011·The Journal of Biological Chemistry·Yongwoo JangUhtaek Oh
Sep 5, 2008·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·William P Cheshire, Phillip A Low
Sep 12, 2020·International Journal of Molecular Sciences·Yulia A Sidorova, Mart Saarma
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Aug 8, 2009·Autonomic Neuroscience : Basic & Clinical·Alun M Davies
Sep 8, 2009·Autonomic Neuroscience : Basic & Clinical·Galina Apostolova, Georg Dechant

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