Sympathetic dystrophy associated with sirolimus therapy

Transplantation
Miguel Gonzalez MolinaJoseph Campistol

Abstract

The reflex sympathetic dystrophy syndrome (RSDS) in organ transplant recipients has only previously been reported in patients treated with calcineurin inhibitors. We retrospectively analyzed 393 renal transplant patients treated with sirolimus, 9 of whom developed RSDS. All the patients reported varying degrees of pain in the legs, affecting the knees, ankles, and/or feet, plus cutaneous erythema. The onset of pain ranged from 1-6 months after transplantation. At the time of diagnosis of RSDS, the mean serum creatinine was 1.4 mg/dL (range 1.0-1.7) and bone scintigraphy with 99mTc pyrophosphate showed increased uptake in all cases. The symptoms remitted 3-10 months after treatment (mean, 4 months) with calcitriol, with or without nifedipine or calcitonin, and in one case with suppression of sirolimus. We conclude that sirolimus therapy may induce RSDS in renal transplant recipients.

References

May 15, 1996·Transplantation·E GoffinC van Ypersele de Strihou
Jan 1, 1997·Archives of Physical Medicine and Rehabilitation·G A Mellick, L B Mellick
Jun 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J V Torregrosa, J M Campistol
Jul 26, 2000·Rheumatology·A T Marshall, A J Crisp
Sep 22, 2001·BMJ : British Medical Journal·S Bhandari, J Eris
Feb 24, 2004·Journal of the American Society of Nephrology : JASN·Henri KreisUNKNOWN Rapamune Maintenance Regimen Trial

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Citations

Aug 4, 2009·Investigational New Drugs·Christophe MassardBernard Escudier
Aug 13, 2010·Expert Opinion on Drug Safety·S Allan Schaffer, Heather J Ross
Dec 18, 2013·European Journal of Pain : EJP·C M van BusselF J P M Huygen
Sep 12, 2015·Seminars in Nephrology·Girish Mour, Christine Wu
Apr 3, 2009·Mayo Clinic Proceedings·Diederik van de BeekEelco F M Wijdicks
Apr 24, 2013·Pain·Ohannes K MelemedjianTheodore J Price
Dec 6, 2017·Journal of Neurotrauma·Khalid C EldahanAlexander G Rabchevsky
Jan 1, 2014·Expert Review of Clinical Immunology·Claudio Ponticelli
Nov 19, 2020·Pharmacological Reviews·Muhammad Saad YousufTheodore J Price
Feb 19, 2019·Joint, Bone, Spine : Revue Du Rhumatisme·Marion MagnolMichel Laroche
Jun 5, 2021·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Luis Pérez de Amezaga-TomásTeresa Fernández-Rodríguez

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